1 / 14

Kentaro Abe et al., Cell, (2007)

NMDA-Receptor Activation Induces Calpain-Mediated b -Catenin Cleavages for Triggering Gene Expression. Kentaro Abe et al., Cell, (2007). NEURONAL ACTIVITY. - REGULATION OF DENDRITIC BRANCH STABILITY BY NEURONAL ACTIVITY

sherri
Download Presentation

Kentaro Abe et al., Cell, (2007)

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. NMDA-Receptor Activation InducesCalpain-Mediated b-Catenin Cleavagesfor Triggering Gene Expression Kentaro Abe et al., Cell, (2007)

  2. NEURONAL ACTIVITY - REGULATION OF DENDRITIC BRANCH STABILITY BY NEURONAL ACTIVITY - ACTIVITY-DEPENDENT MODULATION OF LOCAL CYTOSKELETON AND ADHESION MOLECULES - REGULATION OF DENDRITIC DEVELOPMENT BY ACTIVITY DEPENDENT GENE EXPRESSION Chen Y et al.,J Neurobiol, (2005)

  3. LTP ( long-terrm potentiation) Memory formation Chen Y et al.,J Neurobiol, (2005)

  4. NMDA (N-methyl-D-aspartate) receptor Cooke SF et al., Brain, (2006)

  5. Calpain (calcium-dependent, non-lysosomal cysteine protease) Franco SJ et al., J Cell Sci (2005)

  6. Calpain regulates cell migration Franco SJ et al., J Cell Sci (2005)

  7. Motility-related calpain substrates of Calpain Franco SJ et al., J Cell Sci (2005)

  8. Activity-Dependent Cleavages of b-Catenin by Calpain AVP : NMDA-R antagonist CNQX : AMPA-R antagonist MCPG : mGluR antagonist MDL28170 : calpain inhibitor

  9. Activity-Dependent Cleavages of b-Catenin by Calpain MDL28170 : calpain inhibitor

  10. Nuclear Translocation of Cleaved b-Catenin Fragments AVP : NMDA-R antagonist CNQX : AMPA-R antagonist MCPG : mGluR antagonist MDL28170 : calpain inhibitor

  11. Activation of Tcf-Dependent Gene Transcription by the b-Catenin Fragments AVP : NMDA-R antagonist, MDL28170 : calpain inhibitor

  12. Activation of Tcf-Dependent Gene Transcription by the b-Catenin Fragments MDL28170 : calpain inhibitor

  13. Activation of Tcf-Dependent Gene Transcription by the b-Catenin Fragments

  14. Calpain-Dependent b-Catenin Cleavage and Tcf Activation In Vivo

More Related