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Experimental Trials

Experimental Trials. Oslin ExTENd. Naltrexone. 8 wks Response. Random assignment:. TDM + Naltrexone. Early Trigger for Nonresponse. CBI. Random assignment:. Nonresponse. CBI +Naltrexone. Random assignment:. Naltrexone. 8 wks Response. Random assignment:. TDM + Naltrexone.

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Experimental Trials

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  1. Experimental Trials

  2. Oslin ExTENd Naltrexone 8 wks Response Randomassignment: TDM + Naltrexone Early Trigger for Nonresponse CBI Randomassignment: Nonresponse CBI +Naltrexone Randomassignment: Naltrexone 8 wks Response Randomassignment: TDM + Naltrexone Late Trigger for Nonresponse Randomassignment: CBI Nonresponse CBI +Naltrexone

  3. Pellman ADHD Study A1. Continue, reassess monthly; randomize if deteriorate Yes 8 weeks A. Begin low-intensity behavior modification A2. Add medication;bemod remains stable butmedication dose may vary Assess- Adequate response? Randomassignment: No A3. Increase intensity of bemod with adaptive modifi-cations based on impairment Randomassignment: B1. Continue, reassess monthly; randomize if deteriorate Yes 8 weeks B2. Increase dose of medication with monthly changes as needed B. Begin low dose medication Assess- Adequate response? Randomassignment: B3. Add behavioral treatment; medication dose remains stable but intensityof bemod may increase with adaptive modificationsbased on impairment No

  4. Proposed Study for Drug-Addicted Pregnant Women rRBT 2 wks Response Randomassignment: tRBT tRBT tRBT Randomassignment: Nonresponse eRBT Randomassignment: aRBT 2 wks Response Randomassignment: rRBT rRBT Randomassignment: tRBT Nonresponse rRBT

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