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Cells. Honors Human Anatomy and Physiology Coach Denson. Introduction to Cell. Cells are the structural and physiological unit of all living organisms . A cell’s function is determined by its anatomy. Nerve cells are very long Epithelial cells in the mouth are flat like floor tiles.
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Cells Honors Human Anatomy and Physiology Coach Denson
Introduction to Cell • Cells are the structural and physiological unit of all living organisms. • A cell’s function is determined by its anatomy. • Nerve cells are very long • Epithelial cells in the mouth are flat like floor tiles. • Muscle cells are made of telescoping fibers that can contract. • Although cells vary greatly, they have some things in common. All the various parts make a composite cell.
Composite Cell • Three main parts in a eukaryotic cell. • Cell Membrane • Functions: • Boundary of the cell • Controls entrance and exit to cell • Site of many metabolic reactions • Signal transduction • Characteristics • Extremely thin (only 2 molecules thick) • Flexible • Somewhat elastic • Selectively permeable
Composite Cell • Structure • Double layer of phospholipids • Water soluble substances can’t pass • Lipid soluble substances pass • Embedded proteins • Receptor proteins extend into and out of the cell • Integral proteins form pores and channels. • Peripheral proteins function as enzymes. • Glycoproteins function in recognition and binding.
Composite Cell • Intercellular Junctions • Tight junctions fuse adjacent cell membranes. • Desmosomes join cells in “spot welds” • Gap Junctions connect with tiny tubes that allow movement of materials. 2. Cytoplasm • Functions: • Support Organelles • Medium for diffusion • Provide dissolved materials for metabolism. • Structure-Cytosol(fluid) and cytoskeleton(protein rod and tubule support) • Organelles
Composite Cell: Organelles: • Endoplasmic Reticulum (ER)-Zig-zag appearance in cell • Rough and Smooth (As as “Flow Control” • Structure- • complex membrane tubes, canals, sacs; connect cell membrane and nucleus (Membrane Structure) • Function- • Intracellular transport; provide surfaces for protein synthesis and other metabolic reactions. • Ribosomes • Structure- • Protein (2) and RNA (2) • Function- • Protein synthesis
Composite Cell: Organelles: • Golgi Apparatus • Structure- • Stack of flattened membranous sacs (cisternae) • Function- • Modify, package, deliver proteins produced by ribosomes on rough ER for cellular export • Mitochondria (~1700/Cell) • Structure- • Double membrane; inner membrane consists of folds(cristae); non-chromosomal DNA; motile(moves on it’s own) • Function- • Assist in releasing energy from glucose in the form of ATP(cellular respiration)
Composite Cell: Organelles: • Lysosomes • Structure- • Tiny, membranous sacs containing digestive enzymes; much variety of shape. • Function- • Dismantle debris; destroy worn cell parts; break down engulfed material. • Peroxisomes (special type of lysosomes) • Structure- • Tiny membranous sacs containing enzymes • (Peroxidase, Catalase) specific to the function. • Can break down hydrogen peroxide • Function- • Regulate metabolic reactions that produce dangerous by-products and then break down those by-products
Composite Cell: Organelles: • Centrosomes-made up of 2 centrioles-90 degrees to each other • Structure- • Nonmembranous; 2 cylinders (centrioles) of a protein microtubules at right angles; near the nucleus • Function- • During cell division centrioles migrate to opposite poles, form spindle fibers attached to chromosomes and assist in proper disjunction. • Cilia and Flagella • Structure- • Found on the free surfaces of some cells; distinct cylindrical patter of microtubules, attached to modified centrioles called basal bodies. • Function- • Produce undulating motions for moving the cell or moving material past the cell.
Composite Cell: Organelles: • Vesicles • Structure- • Membranous sacs that vary in size and contents (i.e. lysosomes, peroxisomes, etc.)……enzymes. • Function- • Storage; movement of particles and materials • Microfilaments • Structure- • Mesh or bundle of actin rods-made up of actin (also in muscles) • Function- • Causes various kinds of internal movement in cells
Composite Cell: Organelles: • Microtubules-bigger than microfilaments, made up of tubulin • Structure- • Long, rigid tubes of tubulin • Function- • Provides cytoskeletal framework • Inclusions- not necessary for the cell to stay alive • Structure- • bundle of chemicals that do not directly assist in the function/survival of the cell • Function- • Temporary storage of chemicals (melanin, lipids, etc)
Composite Cell 3. Nucleus • Functions- • Direct the activities of the cell • Safeguard DNA • Structure • Relatively large, spherical • Nuclear envelope (phospholipid membrane) • Double Bilayer • Nuclear Pores-used for nucleotides to enter the nucleus • Nucleoulus • Nonmembranous • Site of ribosome production (RNA part)-where ribosomal RNA is made.
Composite Cell • Nucleus continued…. • Chromatin • Loosely coiled DNA • Protein histones act as spools for chromatin
Movement into and out of the cell • Diffusion • Osmosis • Filtration • Active Transport • Endocytosis/Exocytosis
Diffusion • Movement from greater concentration to lesser concentration. • Simple diffusion requires NO ENERGY • Facilitated diffusion uses a carrier molecule to assist materials across the membrane.
Osmosis • Movement of water from relative greater concentration of water to relative lesser concentration of water. (Selectively Permeable) • Isotonic solution- • Water concentration is equal on both sides of cell membrane. Net movement=0 • Hypertonic solution- • Water is relatively less concentrated in the solution. Water moves across the membrane out of the cell toward the hypertonic solution. • Hypotonic solution- • Water is relatively more concentrated in the solution. • Water moves across the membrane into the cell away from the hypotonic solution.
Filtration • Movement of materials across a membrane due to some force. • Blood pressure-causes blood to be filtered. • Hydrostatic pressure
Active Transport • Opposite of diffusion • Movement of materials from lower concentration to higher concentration • Requires Energy (ATP) • Pump Mechanisms
Endocytosis/Exocytosis • Movement of particles across a membrane, but particles are encapsulated within a membrane vesicle. • Pinocytosis- • Movement of water (“pino”-drink) • Membrane eventually breaks down inside cell and releases water. • Phagocytosis • Movement of food particles (“phago”-eat) • Lysosomes attach and break down material • Receptor mediated Endocytosis • Protein molecules “receive” specific materials and vesicles are formed around them.
Cell Cycle • Stages that a cell goes through from the time it forms until it divides. • Interphase- cell carries out its normal activity; DNA replicates • Mitosis-genetic material divides (Nuclear Division) • Cytokinesis- the rest of the cell divides • Mitosis: • Prophase • Metaphase • Anaphase • Telophase
Mitosis • Cell division/ Nuclear division • Dividing chromosomes
Mitosis: Prophase • Chromatin (indistinguishable strands) condenses into chromosomes (visible bodies) • Nuclear membrane disintegrates • Centrioles begin to migrate to opposite poles
Mitosis: Metaphase • Chromosomes line up on equator between centrioles • Spindle fibers form and attach to chromosome centromeres and centrioles.
Mitosis: Anaphase • Chromosomes are pulled apart to opposite sides. • Centrioles “reel” in chromosomes to opposite poles.
Mitosis: Telophase • Chromosomes begin to unravel into chromatin • Spindle fibers detach and disintegrate • Nuclear membrane reforms around new nuclei
For Mitosis Know… • What’s going on in: • The nuclear membrane • Centrioles • Chromosomes
Cytoplasmic Division • Cytokinesis • Cytoplasm divides • Begins during anaphase; ends when two “new” daughter cells are formed.
Cellular Differentiation • Process of cells taking on special anatomy and physiology • All cells go through this • Stem cells have not differentiated yet.
Control of Cell Division • Loss of telomeres on the ends of chromosomes triggers cell division to stop. • Cell size- • cells reach a certain size and divides • Presence of kinases and cyclins • Hormones • Local Growth Factor • Space availability