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KULIAH PENGANTAR HISTOLOGI SISTEM SARAF

KULIAH PENGANTAR HISTOLOGI SISTEM SARAF. dr. Huriatul Masdar , M.Sc 4 November 20 11. SISTEM SARAF. SISTEM SARAF. SEL-SEL PADA SISTEM SARAF. Sel neuron menerima , memproses dan meneruskan stimuli eksternal

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KULIAH PENGANTAR HISTOLOGI SISTEM SARAF

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  1. KULIAH PENGANTAR HISTOLOGI SISTEM SARAF dr. HuriatulMasdar, M.Sc 4November 2011

  2. SISTEM SARAF

  3. SISTEM SARAF

  4. SEL-SEL PADA SISTEM SARAF • Sel neuron • menerima, memprosesdanmeneruskan stimuli eksternal • mengubahpotensiallistrikdipermukaandalamdanluarmembransel (eksitasi) • stimuli terlokalisirpadasel neuron yang dirangsangataudisebarkankesel neuron lain (termasukselototdanselkelenjar) • melepaskan neurotransmitter • Selglia • mendukungdanmemproteksisel-sel neuron • ikutterlibatdalamaktivitas, nutrisidanpertahananpersarafan

  5. SEL NEURON Terdiridari : • Badansel (perikaryon) - sentralsel neuron - menerima stimuli - binuclear ganglia simpatisdansensoris - BadanNissl: retikulumendoplasmikkasardanribosom • Dendrit - bercabang-cabang - menerima stimulus darilingkungan, selepitelsensoris, dansel neuron lain • Axon - tidakbercabang - membangkitkandanmeneruskanimpulssarafkesel-sel lain (selsaraf, selototdansel-selkelenjar) - synaps : ujung axon yang berhubungandengansel lain

  6. SEL NEURON CEREBELLUM CEREBRUM

  7. JENIS SEL NEURON BERDASARKAN MORFOLOGI • Ganglion cochlear • Ganglion vestibular • retina • mukosaolfaktori mayoritas neuron - Ganglion spinalis (sensoris) - Ganglion cranial

  8. SYNAPS • Penghubungselsarafdenganselsaraf, ataudenganselefektorlainnya (selototdanselkelenjar) • Mengubah electric signal (presynaptic) menjadi chemical signal (post synaptic) • Melepaskanneurotrasmitterselamaprosessynapsis

  9. SEL GLIA Protoplasmic astrocyte Sel Schwann

  10. SISTEM SARAF PUSAT • Cerebrum • Cerebellum • Medulaspinalis Dibungkusolehmeninges: • Duramater • Pia-arachnoid : - piamater (vaskularisasi >>) - arachnoid (tidakadavaskularisasi)

  11. SISTEM SARAF PUSAT (2) Makroskopis : • White matter (substansia alba) • Gray Matter (substansiagrisea) Mikroskopis :

  12. SISTEM SARAF PUSAT (3) Cerebellum Substansia alba Cerebrum Substansiagrisea Medulaspinalis

  13. BLOOD BRAIN BARRIER • Berfungsimencegahmasuknyasubstansiasing/toxic daripembuluhdarahkesistempersarafan • adanya “tight junction” →permeabilitasdaripembuluhdarahotakberkurang • Tidakadanyafenestrasipadasitoplasmaendotel

  14. PLEXUS CHOROIDEUS • invaginasilapisanpiamater • penetrasikedalamventrikel cerebrum (atapventrikel III dan IV sertasebagiandindingventrikel lateral) • terdiridarijaringanikatlonggarpiamater yang dilapisiepitelselapiskubisataukolumnarrendah. • pentingdalamproduksi LCS

  15. LIQUOR CEREBRO-SPINALIS • LCS : • jernih • low density (1.004-1.008 g/ml) • sangatsedikitkandungan protein • bisaditemukanbeberapaseldeskuamasidan 2-5 limfosit/ml

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