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Metabolic effects of CO 2

Metabolic effects of CO 2. Alice Skoumalová. Overview of oxidative fuel metabolism:. Carbon dioxide transport:. CO 2 in the blood: 1. as HCO 3 - (ionization of H 2 CO 3 ) 75-85 % 2. as carbamino groups (CO 2 reacts with amino groups of proteins) 10-15 % 3. dissolved CO 2 5-12 %

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Metabolic effects of CO 2

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  1. Metabolic effects ofCO2 Alice Skoumalová

  2. Overview of oxidative fuel metabolism:

  3. Carbon dioxide transport: CO2 in the blood: 1. as HCO3- (ionization of H2CO3)75-85 % 2. as carbamino groups (CO2 reacts with amino groups of proteins)10-15 % 3. dissolved CO25-12 % Partial pressures air-inspiration air-expiration arterial blood venous blood pO2 (kPa) 21 15,3 12 – 13,3 4,6 - 6 pCO2 (kPa) 0,03 4,4 4,6 – 6 5,3 – 6,6 CO2 + H2O H2CO3 H+ +HCO3- erythrocytes (carbonate dehydratase)

  4. O2 and CO2 transport: Bohr effect (the increase in acidity of hemoglobin as it binds O2, releases H+) Isohydric carriage of CO2(Hb‘s ability to take up H+ with no change in pH through Bohr effect) Chloride shift (the exchange of Cl- and HCO3- between the plasma and the erythrocyte)

  5. Hypercapnia protects against free radical damage duringhypoxia-ischemia: • Stabilization of the iron-transferrin complex • Shift of the oxygen-hemoglobin saturation curve to the right • Effects on metabolism (improve aerobic metabolism, reduced lactate production, ATP generation) • Direct inhibition of the free radicals Perinatal brain hypoxic-ischemic damage Mechanical ventilation Chronic respiratory failure

  6. CO2: protective effect or radical damage ?

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