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Measuring Alcohol and Stress Interactions with Structural and Perfusion MRI

Measuring Alcohol and Stress Interactions with Structural and Perfusion MRI. Chris Wyatt External Collaboration. Introduction.

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Measuring Alcohol and Stress Interactions with Structural and Perfusion MRI

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  1. Measuring Alcohol and Stress Interactions with Structural and Perfusion MRI Chris Wyatt External Collaboration

  2. Introduction • Our goal is to use MRI to examine the effects of chronic alcohol self-administration on brain structure and function in a group of monkeys that have been mother-reared or nursery-reared. • Jim Daunais (WFUHS PI) • Bob Kraft (WFUHS MR Physicist) • Chris Wyatt (VT Engineering) • Killian Pohl (NA-MIC Core 1) Macaca mulatta (rhesus) 1:1 1:2.3 1:3 Size comparison of human, rhesus, and cynomolgus brain.

  3. NA-MIC Related Goal • Implement and validate algorithms for: • brain extraction • white-gray matter segmentation • subcortical structure segmentation Size comparison of human, rhesus, and cynomolgus brain.

  4. Methods Approximate Brain Extraction Initial GM/WM/CSF Segmentation Bias Correction Deformable Registration of Priors * EMS in Slicer 2.6 * Rhesus template and atlas graciously provided by Martin Styner and collaborators

  5. Results: Tutorial • Slicer 2.6 EMS tutorial similar to the existing one • Uses template/atlas created from our data (N=17) • Subject image has been bias corrected and the priors registered • http://bsl.ece.vt.edu/download/NHP-EMSTut.zip

  6. Results: pre-post induction • Comparison of alcohol naive and post-drinking induction (7 animals) No significant change in GM/WM ratio

  7. Macaca fascicularis (cynomolgus) Results: Other ages/species • Using data from similar projects we have also developed atlases for • young rhesus macaque • cynomolgus macaque • Have applied EMS in Slicer 2.6 as well.

  8. Chlorocebus aethiops (vervet) Future: Vervet model • The animals for this project were divided into multiple serial cohorts from a separate project. • That project has switched to a vervet animal model. • So we will begin again with a vervet model in March.

  9. Future: Improved Imaging • This gives us a chance to address some of the imaging issues. • new custom coil • much better uniformity • optimized GM/WM contrast • (CNR ~ 7.5)

  10. Planned Products • Acquisition of baseline vervet images for atlas development - March 08 • Vervet atlas completed - June 08 • Training and Induction 3-4 months • ad-lib access for 12 months • Final structural scans ~August 2009

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