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Cell Signaling

Cell Signaling. “Real Life” Cell Communication: Flight or Fight Response. While watching the movie clip, record at least TWO responses cells have to signals. . Pathways with Friends. Handout Diagram. Steps of Cell Signaling. Reception Signal Transduction Cellular Response. Reception.

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Cell Signaling

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  1. Cell Signaling

  2. “Real Life” Cell Communication: Flight or Fight Response • While watching the movie clip, record at least TWO responses cells have to signals.

  3. Pathways with Friends • Handout • Diagram

  4. Steps of Cell Signaling • Reception • Signal Transduction • Cellular Response

  5. Reception Online Simulation: http://media.pearsoncmg.com/bc/bc_campbell_biology_7/media/interactivemedia/activities/load.html?11&B Molecule the receptor binds to? Action of the receptor? • G-Protein • Tyrosine Kinase • Ligand-Gated Ion Channel • Intracellular Receptor

  6. Signal Transduction Online Simulation: http://media.pearsoncmg.com/bc/bc_campbell_biology_7/media/interactivemedia/activities/load.html?11&C Receptor/s the messenger works with Action of the messenger Second Messengers a. Cyclic AMP b. Calcium ions c. Protein kinases

  7. Cellular Responses Online Simulation: http://media.pearsoncmg.com/bc/bc_campbell_biology_7/media/interactivemedia/activities/load.html?11&D Examples • Testosterone (intracellular receptors) • Cell Reproduction/Cancer (kinase messengers) • Cholera, Viagra (cAMP secondary messengers) • Muscle Contraction (Ca2+ secondary messengers)

  8. Cell Cycle

  9. Cell Cycle Animations • Stages of the Cell Cycle 2) Mitosis Movie

  10. Regulation of Mitosis • Cyclins - Their levels in the cell rise and fall with the stages of the cell cycle.

  11. Cyclin-dependent kinases (Cdks) • G1 (Cdk4) •  S-phase (Cdk2) •  M-phase (Cdk1) • Levels in the cell remain fairly stable, but each must bind the appropriate cyclin (whose levels fluctuate) in order to be activated.

  12. Anaphase-promoting complex (APC) or cyclosome (APC/C) • allows the sister chromatids to separate • degrades the mitotic cyclins

  13. Role of Cyclin & Cdks • Protein kinase + Cyclin = Cdks (Cyclin Dependent Kinases) • Advance the cell at G1 and G2 stages • MPF is a type of Cdk + Cyclin

  14. 4. Cdkportion recycled 5. Cyclinsbuild up and trigger mitosis again 3. Mitosis ends 2. Cyclinbegins to degrade 1. MPF signals mitosis to begin

  15. Cancer • HHMI Video Clip http://www.hhmi.org/biointeractive/cancer/lectures.html • p53 gene affects production of Cdk2 and apoptosis

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