All Pathways

1. All Pathways Extracellular Wnt TGF-β Click to continue Cell-matrix junction Cell-cell junction GPCR Adenylyl Cyclase Black = ligand PIP2 Line = inhibits next step DAG RTK Wnt receptor TGF-β receptor PIP2 PIP3 PI3- kinase G- protein PLC Return to main page Smad Click on any yellow box Click on any yellow box Click on any yellow box PTEN PKB-AKT β- catenin GTP APC PKC Ras cAMP IP3 GTP Apoptosis Previous pathway Kinase cascade Red = inhibits cell growth Ca2+ Go to next pathway FAK mTOR Green = increases cell growth SRC PKA Cam-Kinase Arrow = leads to next step Nucleus (cell growth) Intracellular

2. All Pathways Extracellular Wnt TGF-β Cell-matrix junction Cell-cell junction GPCR Adenylyl Cyclase PIP2 DAG RTK Wnt receptor TGF-β receptor PIP2 PIP3 PI3- kinase G- protein PLC Smad PTEN PKB-AKT β- catenin GTP APC PKC Ras cAMP IP3 GTP Apoptosis Kinase cascade Ca2+ FAK mTOR SRC PKA Cam-Kinase Nucleus (cell growth) Intracellular

3. GPCR Extracellular GPCR Adenylyl Cyclase DAG PIP2 G- protein PLC GTP PKC cAMP IP3 Kinase cascade Ca2+ PKA Cam-Kinase Nucleus (cell growth) Intracellular

4. RTK Extracellular PIP2 DAG RTK PIP2 PIP3 PI3- kinase PLC PTEN PKB-AKT PKC Ras IP3 GTP Apoptosis Kinase cascade Ca2+ mTOR Cam-Kinase Nucleus (cell growth) Intracellular

5. PTEN Extracellular PIP2 PIP3 PI3- kinase PTEN PKB-AKT Apoptosis mTOR Nucleus (cell growth) Intracellular

6. PI3-Kinase Extracellular PIP2 PIP3 PI3- kinase PTEN PKB-AKT Apoptosis mTOR Nucleus (cell growth) Intracellular

7. Cell-Matrix Junction Extracellular Cell-matrix junction Ras GTP Kinase cascade FAK SRC Nucleus (cell growth) Intracellular

8. Cell-Cell Junction Extracellular Cell-cell junction β- catenin APC Nucleus (cell growth) Intracellular

9. Wnt Extracellular Wnt Wnt receptor β- catenin APC Nucleus (cell growth) Intracellular

10. TGF-β Extracellular TGF-β TGF-β receptor Smad Nucleus (cell growth) Intracellular

11. Oncogene/Tumor Suppressor Molecular Pathways Dan Cushman Robert Warren, PhD 2009