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Basket Centrifuge. Applications in Insulin Production. Catherine Chao Danielle Turney Dana Zoratto. Background. Purpose: to remove the WFI and insulin from the insulin crystal. Basket Centrifuge Criteria. Basket Centrifuge Operation. General Operation:. Feed Slurry. Spin Dry. Wash.
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Basket Centrifuge Applications in Insulin Production Catherine Chao Danielle Turney Dana Zoratto
Background Purpose: to remove the WFI and insulin from the insulin crystal
Basket Centrifuge Operation General Operation: Feed Slurry Spin Dry Wash Discharge Spin Dry Process Options: • Modes of Discharge: • Centrifuge stopped • Centrifuge decelerated to slow speed • Discharge at full speed • Operation: • Batch • Semi-Continuous
Basket Centrifuge Types Perforated Basket Centrifuge • Filtration • High solid concentration • Dewatering necessary Imperforate Basket Centrifuge • Sedimentation • High solid concentration • Dewatering not necessary
Centrifuge Type Selection • Vertical Perforate Basket Centrifuge Process Specifications: Type Selection:
Justification of Selection Performance Specifications of Various Centrifuges Schematic Diagram of a Basket Centrifuge
Vertical Basket Centrifuge Centrifuge Specifications: • carbon or stainless steel • Monel • Inconel • Titanium • rubber and plastic coatings (various) Materials of Construction:
Vertical Basket Centrifuge Operation Flow Diagram: Slow-load Slurry Through Pipe Acceleration Deceleration Cake Removal Discharge Through Bottom System Specifications: • Batch Operation • Cake removal: single or multiple ploughs between cycles • High solids recovery in retentate • High wash efficiency • Loading and discharge at reduced speeds
Model Selection Basket Centrifuge Perforated Imperforate Horizontal (discharge at high speed) Batch (discharge while stopped) Vertical (discharge at low speed) Broadbent IPD Deep Basket Centrifuge Krauss-Maffei PT Vertical Centrifuge VZU
Krauss-Maffei PT Size: 1000 x 630 mm Capacity: 250 L Feed Requirement: >3% solids (mass) Materials:Stainless steel Nickel-based alloys, Titanium Rubber-lined steel Special materials Filtering Surface: 2.0 m2 Max Speed: 1250 rpm Weight: 3800 kg Price: request pending - $150, 980 (Equation) Vertical Centrifuge VZU
Broadbent IPD Size: 260 x 160 mm Capacity: 5.6 L Materials: stainless steels Hastelloy Fluorocarbon coatings Filtering Surface: 0.13 m2 Max Speed: 3000 rpm Centrifugal Factor: 1300 g Deep Basket Centrifuge Motor Power: 0.75 kW Weight: 130 kg Price: Request pending - $44,955 (Equation)
Recommendations • Broadbent IPD Ideal performance for process Commonly used in related industry Smaller, more appropriate size than KMPT model Centrifuge Recommendation: Operation and Maintenance: • 2 installed in parallel (final purification step) • Frequent overhaul and maintenance • Residence time dependant on inlet flowrates and composition • With given data, residence time = 3.9 hours • Average cycle time: request pending • Number of multiple cycles will depend on cycle times
Thank you. Questions?