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Evolutionary response of microbes to fluctuating environment: a mechanistic account

Evolutionary response of microbes to fluctuating environment: a mechanistic account . Xiao Yi University of Minnesota 06.08.11. QUESTIONS. How microbes (gene expression system) adapt to fluctuating environment? Bet-hedging v.s . sensing

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Evolutionary response of microbes to fluctuating environment: a mechanistic account

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  1. Evolutionary response of microbes to fluctuating environment: a mechanistic account Xiao Yi University of Minnesota 06.08.11

  2. QUESTIONS • How microbes (gene expression system) adapt to fluctuating environment? • Bet-hedging v.s. sensing • What roles signals play to determine microbial response? • Is biochemical stochasticity subject to natural selection to help solve the problem?

  3. Project • Start with a bistableoperon Choi et al. Science (2008)

  4. Project • Construct an operon with fitness consequences

  5. Project • Competing mutants with wild type or each other • Make mutants of the regulatory protein with differential affinities to the operator

  6. Motivation • Problem: differential equations are clumsy to describe the system given fluctuating environment • Inspiration: individual based model seems more natural to model the system

  7. Challenges • My goal: • Can I use individual based model and is it better than the traditional ones?

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