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BDNF Induces Late-phase LTP of C-fiber Evoked Field Potentials in Rat Spinal Dorsal Horn

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BDNF Induces Late-phase LTP of C-fiber Evoked Field Potentials in Rat Spinal Dorsal Horn

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    1. BDNF Induces Late-phase LTP of C-fiber Evoked Field Potentials in Rat Spinal Dorsal Horn

    2. It is easier to find men who will volunteer to die, than to find those who are willing to endure pain with patience. ----Julius Caesar

    3. Are We Lost? Background LTP and BDNF Background Some More Anatomy and Pain Results and Interpretations THE Paper Concluding Conclusions

    4. LTP: It PotentiatesOr Does It? J/K, It Does.

    5. Its Never Too Early to be Late Early phase (E-LTP) Independent of protein synthesis Lasts up to 3 hours Late phase (L-LTP) Protein synthesis involved Lasts longer than 3 hours, up to entire life SUPER DUPER EXTREMELY SUBJECTIVE!!

    6. LTP is the BMOC aka The Leo Da Vinci of Neuroscience

    7. Hi, My Name Is: BDNF

    8. Hi, My Name Is: BDNF

    9. Hi, My Name Is: BDNF

    10. Hi, My Name Is: BDNF

    11. Hi, My Name Is: BDNF

    12. Lets Learn Anatomy!

    13. Anatomy is FUN!

    14. Its All Fun and Games Until Someone Gets Their Face Burned Off Nociception: detection of pain 2 types: mechanical and polymodal Different signaling molecules Different molecules enhance response

    15. Its All Fun and Games Until Someone Gets Their Face Burned Off

    16. Its All Fun and Games Until Someone Gets Their Face Burned Off Central sensitization Two main pathological pain states Hyperalgesia Allodynia

    17. LTP Makes it Painful

    18. Sometimes, a Little Doesnt Go a Long Way

    19. Alls I Need is a Match, a Pen, and a Compass Adult male Sprague-Dawley rats Left sciatic or sural nerve was dissected Utilized hook electrodes for stimulation Field potentials recorded Both HFS and LFS

    20. UmI Might Need a Map Spared nerve injury (SNI) Peroneal and tibial nerves cut Mechanical sensitivity through von frey hairs Drugs!!

    21. Look at All the Pretty Squiggly Lines and Dots! Fig 1Fig 1

    22. Meh. Fig 2 and 4Fig 2 and 4

    23. I Was in Track in High SchoolAs the Waterboy Fig 3, 6, 8Fig 3, 6, 8

    24. You Got Your Freshmen, ROTC Guys, Preps, J.V. Jocks, Asian Nerds, Cool Asians, Varsity Jocks, Unfriendly Black Hotties, Girls Who Eat Their Feelings, Girls Who Don't Eat Anything, Desperate Wannabes, Burnouts, Sexually Active Band Geeks, the Greatest People You Will Ever Meet, and the Worst. Beware of Plastics. Fig 5Fig 5

    25. Last, But Not Least Fig 7Fig 7

    26. What Color is Your Mood? rhBDNF ? LTP in spinal dorsal horn C-fibers Blocking TrkB affected BDNF- and LFS-induced LTP BDNF differentially involved in LTP stim patterns? Inhibiting protein synthesis prevented BDNF-induced LTP

    27. What is Your Motivation? BDNF-LTP NMDA-dependent BDNF occluded further potentiation in L-LTP Blocking NF-kB prevented BDNF-LTP Inhibiting ERK and p38 MAPK? no BDNF-LTP P38 MAPK and JNK prevents LTP in injured rats Needed for initiation and maintenance of neuropathic pain in DH Although JNK not block LTP!!!Although JNK not block LTP!!!

    28. Dont Forget to Tip Your Waitress

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