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Marginal zone (IgM + memory) B cells and IgA antibodies respond to gut microbial products

Antibody and B cell responses may control circulating lipopolysaccharide in patients with HIV infection. Lim A 1 , Amini A 1 , D’Orsogna L 2 , Rajasuriar R 3 , Lewin S 3,4 , Purcell D 5 , Price P 1 , French MA 1,2

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Marginal zone (IgM + memory) B cells and IgA antibodies respond to gut microbial products

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  1. Antibody and B cell responses may control circulating lipopolysaccharide in patients with HIV infection Lim A1, Amini A1, D’Orsogna L2, Rajasuriar R3, Lewin S3,4, Purcell D5, Price P1, French MA1,2 1. School of Pathology and Laboratory Medicine, University of Western Australia 2. Department of Clinical Immunology, Royal Perth Hospital, Perth 3. Alfred Hospital, Melbourne 4. Monash University, Melbourne 5. Department of Microbiology and Immunology, University of Melbourne

  2. Marginal zone (IgM+ memory) B cells and IgA antibodies respond to gut microbial products Kraal G. Nature Immunol 2008; 9:11-12 Cerutti A, Rescigno M. Immunity 2008; 28:740-50

  3. Plasma levels of LPS are inversely correlated with serum levels of antibodies to LPS in ART-naïve HIV patients

  4. LPS-specific IgG antibodies correlate with IgM+ memory B cell counts in ART-naïve patients

  5. Better immune reconstitution on ART is associated with lower plasma LPS and serum anti-LPS

  6. Summary • In ART-naïve patients: • Serum levels of IgG and IgA antibodies to LPS are negatively correlated with plasma LPS levels • Serum levels of IgG anti-LPS are positively correlated with circulating IgM+ memory B cell counts • Serum IgA levels are strongly correlated with serum levels of IgA antibodies to LPS • In ART-treated patients: • Better immune reconstitution (higher CD4+ T cell and switched memory B cell counts) is associated with lower levels of LPS and antibodies to LPS

  7. Conclusions • Plasma LPS levels in ART-naive HIV patients may be determined by immune responses against LPS, as well as by increased gut permeability • High serum IgA levels in untreated HIV infection may reflect an IgA antibody response against LPS

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