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Yuan Liu, PhD Chief, Office of International Activities

NIH Grantsmanship Elements of Success. Yuan Liu, PhD Chief, Office of International Activities Director, Computational Neuroscience and Neuroinformatics Program NINDS, NIH. Penn State August 28, 2007. National Institutes of Health. Office of the Director. National Institute

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Yuan Liu, PhD Chief, Office of International Activities

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  1. NIH Grantsmanship Elements of Success Yuan Liu, PhD Chief, Office of International Activities Director, Computational Neuroscience and Neuroinformatics Program NINDS, NIH Penn State August 28, 2007

  2. National Institutes of Health Office of the Director National Institute of Allergy and Infectious Diseases National Institute on Aging National Institute on Alcohol Abuse and Alcoholism National Institute of Arthritis and Musculoskeletal and Skin Diseases National Cancer Institute National Institute of Child Health and Human Development National Institute on Deafness and Other Communication Disorders National Institute of Dental and Craniofacial Research National Institute of Diabetes and Digestive and Kidney Diseases National Institute on Drug Abuse National Institute of Environmental Health Sciences National Eye Institute National Institute of General Medical Sciences National Heart, Lung, and Blood Institute National Human Genome Research Institute National Institute of Mental Health National Institute of Neurological Disorders and Stroke National Institute of Nursing Research National Institute of Biomedical Imaging and Bioengineering National Center for Complementary and Alternative Medicine National Library of Medicine National Center on Minority Health and Health Disparities National Center for Research Resources Fogarty International Center Clinical Center Center for Information Technology Center for Scientific Review

  3. How does NIH Support Research? • Grants • Investigator-initiated research grants (majority) • Program Announcements (multiple receipt dates) • Request for Applications (one time with set-aside $) • Contracts • Cooperative Agreements NIH Guide http://grants.nih.gov/grants/guide/index.html

  4. When to Submit Your Application? • There are three overlapping cycles per year • Cycle ICycle II Cycle III R01 February 5June 5 October 5 R21, R03 February 16June 16October 16 Review JuneOctober February Council SeptemberJanuary May Award DecemberApril July

  5. Grant Application PI Grant Award What Happens to Your Application? CSR Referral Office Review Initial Review Group Study Sections Scientific Review Administrators Funding Institute Program Directors Advisory Council Institute Director Grants Management

  6. What Should Be in the Application? • Face Page – Title of Project • Abstract • Key Personnel • Budget • Biographical Sketch • Resources • Research Plan • Specific Aims • Background and Significance • Preliminary Studies • Research Design and Methods • Human Subjects and Vertebrate Animals • Literature Cited • Letters of Support

  7. Abstract • Research goal and rational • General hypothesis and aims • Methodological approaches • Significance

  8. Specific Aims • Hypothesis-driven • Focused • Realistic

  9. Background • Intimate familiarity with the field • In-depth knowledge about the research • Thorough literature review • Appropriate credit

  10. Preliminary Studies • Demonstrate expertise & feasibility • Appropriate amount • Critical interpretation

  11. Design and Methods • Hypothesis-driven, not “fishing expedition” • Use sate-of-the art technologies • Address pitfalls and alternative plans • Apply appropriate statistical and/or informatics analysis • Provide adequate details

  12. What is a Study Section?

  13. What is a Study Section?

  14. Significance Approach Innovation Investigator Environment What are the Review Criteria?

  15. Does this study address an important problem? If the aims of the application are achieved, how will scientific knowledge be advanced? What will be the effect of these studies on the concepts or methods that drive this field? Significance

  16. Are the conceptual framework, design, methods, and analyses adequately developed, well-integrated, and appropriate to the aims of the project? Does the applicant acknowledge potential problem areas and consider alternative tactics? Approach

  17. Does the project employ novel concepts, approaches or methods? Are the aims original and innovative? Does the project challenge existing paradigms or develop new methodologies or technologies? Innovation

  18. Is the investigator appropriately trained and well suited to carry out this work? Is the work proposed appropriate to the experience level of the principal investigator and other researchers? Investigator

  19. Does the scientific environment in which the work will be done contribute to the probability of success? Do the proposed experiments take advantage of unique features of the scientific environment or employ useful collaborative arrangements? Is there evidence of institutional support? Environment

  20. What do the Reviewers Want to Know? • WHY is your research important? (background, significance, innovation) • WHAT are you proposing to do? (research plan, specific aims) • HOW are you going to do it? (approaches, experimental design, method and analysis) • Are YOU the best person to do it? (investigator, preliminary data, environment)

  21. How is an Application Reviewed? • Primary reviewer • Describes application and provides critiques (5-10 min) • Secondary reviewer(s) • Adds differences or enhancements to the primary (1-2 min) • Committee • General discussion (all members) • Score • First given by assigned reviewers • All committee members then give individual score • SRA • Calculates the score and the percentile • Prepares the Summary Statement

  22. What are in the Summary Statement? SUMMARY STATEMENT Dr. John Johnson ( Privileged Communication ) Release Date: 03/01/2006 (301) 496-0000 JJ00@.nih.gov SMITH, JOE PHD Application Number: 2 R01 MH99999-06A1 UNIVERSITY OF SAN SIMEON DEPT OF PSYCHOPHYSIOLOGY 10550 CASTLE ROAD SAN SIMEON, CA 93452 Review Group: LAM Neurobiology of Learning and Memory Study Section Meeting Date: 02/16/2006 Council: MAY 2006 PCC: 72-NBT Requested Start: 07/01/2006 Dual IC(s): NSDA Project Title: NEURAL CONTROL OF INVOLUNTARY EXUBERANCE SRG Action: Priority Score: 138 Percentile: 3.5 Human Subjects: 10-NO HUMAN SUBJECTS INVOLVED Animal Subjects: 30-ANMLS INV.-VERIFIED, NO SRG CONCERNS OR COMMENT

  23. What is the Next Step? Two stages of review: • Study Section • Scientific and technical merit • National Advisory Council • Scientific, clinical and lay representation • Focus on policy and strategy • Make recommendations to the Institute Director

  24. What are the Funding Criteria? • Scientific Merit • Priority score/percentile • Program Relevance • Is the project related to the mission of the funding institute? • Program Balance • Are many similar projects already funded? • Availability of Funds • Dose the funding institute have sufficient resources available at the time?

  25. What is the Outcome of Review? • Fundable Receive funding Contact Program Director • Gray Zone Resubmission • Unfundable

  26. Respond to All criticisms Provide explicit responses Supply additional data and material Be polite Be persistent! How to Write a Successful Revised Application?

  27. Pearl of Wisdom • Do not submit prematurely • Follow instructions • Be a “reviewer” of your own application • Have at least three people read your application prior to submission • Write clearly!

  28. Some Useful Websites • “All About Grants” Tutorials http://www.niaid.nih.gov/ncn/grants/ • The NIH Peer Review Process http://cms.csr.nih.gov/AboutCSR/OverviewofPeerReviewProcess.htm • NIH Guide http://grants.nih.gov/grants/guide/index.html • NIH CSR Study Section Roster http://www.csr.nih.gov/Roster_proto/sectionI.asp • NIH Institutes Centers and Offices http://www.nih.gov/icd/

  29. Funding Opportunities - Bioengineering • PA-06-418 Exploratory/Developmental Bioengineering Research Grants (EBRG) [R21] • Innovative, high risk/high impact research in new areas • Minimal or no preliminary data required • PA-07-279 Bioengineering Research Grants (BRG) [R01] • Basic and applied multi-disciplinary research • Important biological, bioengineering or medical problems • Hypothesis-driven, discovery-driven or design-directed • PAR-07-352 Bioengineering Research Partnerships (BRP) [P01] • Multi-disciplinary research team • Integrative, systems approaches http://www.becon.nih.gov/becon_funding.htm#becon

  30. Funding Opportunities – Computational & Informatics • PA-06-411 Exploratory Innovations in Biomedical Computational Science and Technology (R21) • Innovative, with high risk/high impact research in new areas • Minimal or no preliminary data required • PAR-07-344 Innovations in Biomedical Computational Science and Technology (R01) • Database design, graphical interfaces, data querying, retrieval, visualization, manipulation, integration and analytical tools • Computational modeling & simulation • PAR-07-235 Continued Development and Maintenance of Software • Continued development, maintenance, testing and evaluation of existing biomedical informatics/computational biology software and its applications to broader biomedical research communities http://www.bisti.nih.gov/bistic_funding.cfm

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