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History of Microbiology. 1500’s -1900’s. What is microbiology. Study of any organism too small to be seen with the human eye. Microorganisms -- Oldest life form on earth. (3.5 billion years ago). 1500’s. Before the 1500’s most theories of disease were based on superstition.
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History of Microbiology 1500’s -1900’s
What is microbiology • Study of any organism too small to be seen with the human eye. • Microorganisms -- Oldest life form on earth. (3.5 billion years ago)
1500’s • Before the 1500’s most theories of disease were based on superstition. • No knowledge of microorganisms. • Thought that you can get disease from another person who was sick, but didn’t know why.
1600’s • Robert Hooke and Anton van Leeuwenhoek started using crude microscopes Hooke’s microscope
1600’s • Van Leeuwenhoek observed what we now call bacteria and protists, he called them “animalcules”. Called “Father of Microbio.” van Leeuwenhoek’s microscope
1600’s • Francesco Redi 1668 Disproved Spontaneous Generation. • It was thought that organisms arose from inorganic or rotting organic material. • His experiment:Francesco took eight jars, placed meat in all the jars, but covered four of the jars with muslin. Maggots developed in the open jars but did not develop in the muslin-covered jars. • Proving that organisms arose from parental organisms- biogenesis
1700’s • John Fisher- Studied venereal diseases - found it was caused by a single bacteria, meisseria gonorrhoeae. • Edward Jenner 1789- Developed small pox vaccination by using a milder disease, cowpox. He took liquid from the sores a patient with cowpox and put it into a healthy person. Then gave that healthy person liquid from a patient with small pox and discoved that the healthy person didn’t get sick. Risky experiment gave us the first way to prevent disease.
1800’s More prevention • Ignaz Semmelweis, hand washing before surgery could prevent “childbirth fever” ie. Strep. Drs. would deliver babies w/o washing hands, or after performing autopsies on women who had died from childbirth fever. • Joseph Lister: father of antiseptic surgery concept, sanitation/hygene procedure (food handlers, water). Connected work of Semmelweis and Pasteur to develop and popularize the chemical inhibition of infection during surgery. (washed surgical wounds with phenol (carbolic acid)) AKA: Listerine
1800’s • Louis Pasteur (1864)-demonstrated that microorganisms are present in air not created by the air- further disproving spontaneous generation. Helped developed the germ theory of disease (microorganisms may be the cause of some or all disease).
Germ Theory of Disease • Robert Koch • Bacillus antraxis- caused anthrax- could take the blood of infected animals and injected blood to healthy sheep and healthy sheet got the disease. • Koch’s postulates- proves specific bacteria cause a specific disease. • 1876
Koch’s postulates • 1. Microorganism must be present in every case of the disease. • 2. The microorganism must be isolated from the diseased host and grown in pure culture. • 3. The disease must be reproduced when the pure culture of the microorganism is inoculated into a healthy animal. • 4. The organism must be recoverable from the experimental infected host.
1500-1800’s • Disease was caught from someone who was sick. • Microorganisms exist! • Disease was caused by a microorganism, that can be transferred from another person.
The Golden Age of Bacteriology • 1877-1900 -diseases found caused by bacteria. • Tuberculosis • Typhoid • Staphlococcal disease • Strep • Tetnus • Diptheria • Pneumococcus • Cholera • Gonococcus • Meningeococcus
Viruses! • Dimitri Iwanowski (~1890-1900) first to discover viruses. • Tobacco mosaic virus
1900’s • Alexander Fleming 1920’s- First antibiotics (penicillin) • Fleming discovered that a mold accidentally growing on one of his petri dishes had anti-bacterial activity.
