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CELL SIGNALING (BIO-203)

CELL SIGNALING (BIO-203). Credit Hrs 3. Course Contents. Overview of cell signaling Principles of cell signaling Types of ligands and receptors Signaling through enzyme liked cell-surface receptors Receptor tyrosine kinases and non-receptor tyrosine kinases

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CELL SIGNALING (BIO-203)

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  1. CELL SIGNALING (BIO-203) Credit Hrs 3

  2. Course Contents • Overview of cell signaling • Principles of cell signaling • Types of ligands and receptors • Signaling through enzyme liked cell-surface receptors • Receptor tyrosine kinases and non-receptor tyrosine kinases • Signaling via receptor tyrosine kinases • Signaling via tyrosine kinase associated receptors • Signaling via receptor serine-/threoninekinases • Signaling through G protein linked receptors • Small GTPases • G protein coupled receptors • Lipid (2nd messengers)-mediated cell signaling • Synaptic signaling • ATP-signaling • Purinergic (P2X and P2Y) signaling • iNOSsiganling • Cell adhesion molecules • Signaling events in acute inflammation (native immunity) • Events at the postcapillaryvenule • Wound repair • Hematopoiesis • Why and how do cancer cells become independent of extracellular signals? • Selected examples • Plant cell signaling (role of growth factors, hormones and pheromones) • Plant defense mechanism • Signaling in microbes

  3. Recommended Books • Molecular Cell Biology by Lodish and co. 6th Ed • Molecular Biology of the Cell by Bruce Albert and Dennis Bray. Garland Publishing Inc, New York and London. • Handbook of Cell SignalingVol 1-3, by Ralph Bradshaw, and Edward Dennis. • Cell Signalling, by John T. Hancock, 2nd ed. Oxford University Press. • Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volume 2by RakeshSrivastava. • Cell Signaling and Growth Factors in Development: From Molecules to Organogenesis by Klaus Unsicker (Editor), Kerstin Krieglstein. • Signal Transduction by Bastien D. Gomperts. • The Biochemistry of Cell Signallingby Ernst J. M. Helmreich.

  4. Total Marks • First OHT 15 marks • Second OHT 15 marks • Final Exam 50 mark • Quizzes (3-6)10 marks • Assignment/project /presentation10 marks

  5. Time table • Cell Signaling Wed (1:30-3:00pm) Fri (9:00-10.30) • Clinical Genetics Tues (1:00-2:30) Thurs (12:30-2:00)

  6. Those who know Light in the world are those, who know Guides of mankind are those, who know When looking for the road to God And Prophet, ask from those, who know The alchemist in his research Finds sympathy from those, who know A desert stone will turn to gold In company with those, who know Those are not humans, only shells The empty ones, who do not know (Rehman Baba)

  7. Believe in yourself • “Don't be satisfied with stories, how things have gone with others. Unfold your own myth.”  Rumi • “Life is too short to waste any amount of time on wondering what other people think about you. In the first place, if they had better things going on in their lives, they wouldn't have the time to sit around and talk about you. What's important to me is not others' opinions of me, but what's important to me is my opinion of myself.”  Anonymous

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