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Principles of Pharmacology The Pathophysiologic Basis of Drug Therapy

Explore the pharmacology of viral infections with insights into the viral life cycle and pharmaceutical interventions. Discover how antiviral nucleoside analogues, protease inhibitors, and other drugs target specific stages of viruses like HIV and influenza. This chapter delves into the mechanisms of action of medications such as acyclovir, maraviroc, and enfuvirtide, shedding light on their roles in combating viral infections.

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Principles of Pharmacology The Pathophysiologic Basis of Drug Therapy

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  1. Principles of PharmacologyThe Pathophysiologic Basis of Drug Therapy

  2. Chapter 37 Pharmacology of Viral Infections

  3. Viral Life Cycle and Pharmacologic Intervention • Figure 37-1

  4. Life Cycle of HIV • Figure 37-2

  5. Model for HIV gp41-Mediated Fusion and Maraviroc and Enfuvirtide (T-20) Action • Figure 37-3

  6. Uncoating of Influenza Virus and Effectof Amantadine and Rimantadine • Figure 37-4

  7. Antiviral Nucleoside and Nucleotide Analogues • Figure 37-5

  8. Mechanism of Action of Acyclovir • Figure 37-6

  9. Nonnucleoside DNA Polymerase and Reverse Transcriptase Inhibitors • Figure 37-7

  10. Integration of HIV DNA into Cellular DNA and Effect of Anti-HIV Integrase Inhibitor • Figure 37-8

  11. Anti-HIV Protease Inhibitors • Figure 37-9

  12. Steps in the Evolution of Ritonavir • Figure 37-10

  13. Structure-Based Design of Neuraminidase Inhibitors • Figure 37-11

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