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Huntington’s Disease

Huntington’s Disease. By: Austin Rogers, Josh Ellis, Nick Horn & Nathan Comer. Description. Huntington’s Disease Genetic disease in which nerve cells in certain parts of the brain waste away or degenerate. Causes of Huntington’s.

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Huntington’s Disease

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  1. Huntington’s Disease By: Austin Rogers, Josh Ellis, Nick Horn & Nathan Comer

  2. Description Huntington’s Disease • Genetic disease in which nerve cells in certain parts of the brain waste away or degenerate.

  3. Causes of Huntington’s • Defect on Chromosome 4; causes a part of DNA, CAG, to repeat, which makes it occur many more times than necessary • Normal— CAG repeated 10-28 times • Huntington’s— CAG repeated 36-120 times • As defect is passed down, the repeats go up in quantities • This causes a higher chance of developing it at a younger age

  4. Forms • Most common is adult-onset Huntington’s Disease • Symptoms usually develop in mid-30s and 40s • Less common is early-onset Huntington’s Disease • Symptoms begin in childhood or adolescence

  5. Signs and Symptoms • Behavioral Disturbances • Hallucinations • Irritability • Moodiness • Restlessness or Fidgeting • Paranoia

  6. Treatments • No cure and no stop for it, but there are ways to slow it down • Dopamine blockers may help reduce abnormal behaviors • Drugs like amantadine and tetrabenazine

  7. Autosomal Linked • Huntington’s Disease is a dominant, autosomal trait found on chromosome 4

  8. Pics Kathleen Edward The human brain, showing the impact of HD on brain structure in the basal ganglia region of a person with HD (top) and a normal brain (bottom)

  9. Story of 7-Year Old Kathleen Edward https://www.youtube.com/watch?v=xVWVTc6dGaw

  10. Study Guide for Huntington’s Disease • Genetic disease in which nerve cells in certain parts of the brain waste away or degenerate. • Defect on Chromosome 4; causes a part of DNA, CAG, to repeat • Normal— CAG repeated 10-28 times • Huntington’s— CAG repeated 36-120 times • As defect is passed down, the repeats go up in quantities • No cure and no stop for it, but there are ways to slow it down • Dopamine blockers may help reduce abnormal behaviors • Dominant, autosomal trait found on chromosome 4

  11. Sources • http://media.tumblr.com/tumblr_lm2jg1CkMi1qgb95b.gif • https://www.youtube.com/watch?v=xVWVTc6dGaw • http://www.ajnr.org/content/25/10/1715/F3.large.jpg • http://i.i.com.com/cnwk.1d/i/tim/2010/10/13/kathleen-edward-%286%29_620x414.jpg • http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001775/

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