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Understanding LIN-12 and EGF Receptor Signaling Pathways in Cell Fate Determination

Explore the intricate signaling mechanisms of LIN-12 and EGF receptors in cellular fate decisions, including totipotency, inhibition, and gradient regulation. Learn about regulatory networks and cell destiny patterns.

timothy-davidson
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Understanding LIN-12 and EGF Receptor Signaling Pathways in Cell Fate Determination

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  1. Sinalização do receptor LIN-12 Sinalização do receptor de EGF VPC´s inicialmente totipotentes Sinal de EGF inibido Gradiente do sinal de EGF Rede reguladora Padrão estável Distante Intermediária Próxima Intermediária Distante Padrão do destino celular Sternberg, Science 303, 637-638, 2004

  2. Todas as células vulvais destruídas por laser, exceto P8.p Como uma célula entra e sai de um órgão AC = azul Matriz extracelular = amarelo Células indutoras ou invasoras = violeta Podbilewicz, Dev. Cell, ?, ?

  3. Morfogênese da vulva em animais selvagens e mutantes sqv-4(n2827) v = espaço extracelular da vulva utse = processo citoplasmático fino de uma célula uterina u = espaço extracelular do útero Hwang & Horvitz, PNAS 99, 14224-14229, 2002

  4. Modelo da função das proteínas SQV na biossíntese do esqueleto de heparan e condroitina Hwang e cols., Nature 423, 439-443, 2003

  5. Biossíntese de glicosaminoglicanos Hwang & Horvitz, PNAS 99, 14224-14229, 2002

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