1 / 29

Presentation to CA Environmental Health Tracking March 19, 2003

Presentation to CA Environmental Health Tracking March 19, 2003. Project Goals. Assess the need for biomonitoring within the State Identify new laboratory biomonitoring methods or expand current methods (given the needs)

tomas
Download Presentation

Presentation to CA Environmental Health Tracking March 19, 2003

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Presentation to CA Environmental Health TrackingMarch 19, 2003 A project of the California Department of Health Services and Impact Assessment Inc.

  2. Project Goals • Assess the need for biomonitoring within the State • Identify new laboratory biomonitoring methods or expand current methods (given the needs) • Identify public health research projects within which to achieve goals 1 and 2. • Write grant to implement plan. A project of the California Department of Health Services and Impact Assessment Inc.

  3. Project Background • CDC funded 33 States to a conduct planning process for biomonitoring • Final Plan due June 30, 2003 • Distribution of funds: • $200,000-$3,000,000 • Larger funding to consortium grants • 2-10 grant awardees A project of the California Department of Health Services and Impact Assessment Inc.

  4. Planning Structure • Needs Assessment of health hazards & health effects (surveys, inventory, reports) • Selection of Biomonitoring Projects • Implementation Plan with Partners A project of the California Department of Health Services and Impact Assessment Inc.

  5. I. Needs Assessment

  6. Local Officials (N=27) Tribal and NGOs (N=42) Pesticides (59%) Pesticides (43%) Lead (59%) Mercury (24%) ETS (41%) Organochlorines (21%) MTBE (33%) Lead (19%) Particulate matter (26%) Particulate matter (19%) Mercury (15%) ETS (17%) Organochlorines (15%) Arsenic (14%) VOCs (15%) VOCs (14%) Toxic Substances A project of the California Department of Health Services and Impact Assessment Inc.

  7. Local Officials(N=26) Tribal and NGOs (N=32) Resp disorders (100%) Cancer (75%) Cancer (89%) Resp disorders (47%) Heart disease (50%) Devel. disabilities (34%) Devel. disabilities (31%) Endocr. disorders (34%) Health Effects A project of the California Department of Health Services and Impact Assessment Inc.

  8. Researcher Survey Results • Analyze samples • Increased throughput • Create population reference ranges • Develop methods & reference support A project of the California Department of Health Services and Impact Assessment Inc.

  9. Baseline Laboratory Inventory • Broad range of biomonitoring methods and chemical testing • Potential to form Laboratory Network with State, Local, and Private Partners • Laboratory has capability to test for Toxic Substance of concern • Primary laboratory challenge is capacity to run large numbers of samples to meet research need A project of the California Department of Health Services and Impact Assessment Inc.

  10. Needs Assessment Conclusions • Community and Researcher survey respondents agree that the toxic substances of most concern are Pesticides, Heavy Metals and ETS. • This is supported by a review of selected reports. • Laboratory capacity either exists or could be developed by the Laboratory Network A project of the California Department of Health Services and Impact Assessment Inc.

  11. Important areas for biomonitoring • Pesticides • Heavy metals (lead, mercury, arsenic) • Cost-effective laboratory methods • Emerging Concerns (PBDEs -brominated flame retardants, and Phthalates - plasticizers) • Exposure markers for air pollutants (benzene, PAHs) A project of the California Department of Health Services and Impact Assessment Inc.

  12. II. Selection of Biomonitoring Projects

  13. Methodology Selection Criteria & Decision Flow Step 1: Scientific Criteria (toxicity, exposure, preliminary lab feasibility, hypothesis, study design, study population) Step 2: Collaborator Infrastructure Step 3: Responsible Research Step 4: Public Health Benefit, Support & Impact Step 5: Sampling & Laboratory Feasibility A project of the California Department of Health Services and Impact Assessment Inc.

  14. Project Aim Project Aim CHARGE Autism, env & genetic factors Bay Area Teacher’s Study levels of selected chemicals Birth Defects Environmental & genetic factors Kaiser Cohort chemicals that affect fertility Mercury Hg in pregnant fish eaters Breast milk Monitoring POPs in breast milk CHAMACOS Pesticides & pre, postnatalexps Alameda County Asthma Study Chemicals that affect asthma Normative Levels in pregnant women Bayview Hunter’s Point Chemicals that affect asthma Identified Potential Collaborators A project of the California Department of Health Services and Impact Assessment Inc.

  15. I. Selection Process Criteria Scientific Collaborator Support Lab Feasibility Feasibility for biomarkers of exposure for air contaminants: 1. West Oakland HT Pilot 2. Bayview Hunter’s Point 10 potential projects identified 8 potential Projects remaining Eliminated A project of the California Department of Health Services and Impact Assessment Inc.

  16. II. Selection Process Advisory Committee Project Selections Criteria Responsible Research Public Health Benefits Public Support Results CHARGE CHAMACOS ___________________ CA Birth Defects Body Burden (Breast milk) ___________________ Normative Kaiser ___________________ Mercury Teacher’s cohort 8 potential projects A project of the California Department of Health Services and Impact Assessment Inc.

  17. Top Projects of Interest CHARGE CHAMACOS Body Burden methods development Birth DefectsMS-AFP feasibility A project of the California Department of Health Services and Impact Assessment Inc.

  18. III. Implementation Planning

  19. Current Planning Steps • Meetings with Partners to understand each others needs and strengths • Define roles & timelines for each collaboration • Continue planning & conversations with collaborators • Develop tiered approach based on potential funding rewards A project of the California Department of Health Services and Impact Assessment Inc.

  20. Opportunities: Implementation Plan • Target chemicals • Health Endpoints • Normative Data • Breast milk methods development A project of the California Department of Health Services and Impact Assessment Inc.

  21. 1. Target Chemicals • Pesticides (OPs, Pyrethroids, Organochlorines) • Noncoplanar PCBs • PBDEs • Metals (lead, mercury, metals panel) • Phthalates A project of the California Department of Health Services and Impact Assessment Inc.

  22. 1. Target Chemicals • Consistent with Pew Report recommendations for exposure tracking • Consistent with CA Biomonitoring Needs Assessment Report A project of the California Department of Health Services and Impact Assessment Inc.

  23. 2. Health Endpoints • CHARGE:What are the environmental and genetic factors that influence the risk and severity of autistic and developmental delay/ mental retardation? • CHAMACOS:Is in utero and/or postnatal pesticide exposure associated with poorer neurodevelopment or somatic growth? A project of the California Department of Health Services and Impact Assessment Inc.

  24. 3. Normative Data • A normative study uses samples from “normal” healthy people to provide “normal” background ranges of substances in the population. • Tremendous value for comparative purposes such as in determining whether levels of environmental chemicals are unusually high among certain individuals • Monitoring trends in the population A project of the California Department of Health Services and Impact Assessment Inc.

  25. 3. Normative Data – MS-AFP samples • Laboratory feasibility for maternal serum from the alpha-fetoprotein (MS-AFP) specimens • Exploratory study with GDB • Normative data for pregnant women • Sample size and contamination? A project of the California Department of Health Services and Impact Assessment Inc.

  26. 3. Normative Data – CHARGE Study • Use the 700 controls (and their parents) to establish reference ranges. • Provide laboratory support for the analysis of selected chemicals requested by the CHARGE study. • Perform additional analyses among the controls to determine levels for metals in urine. A project of the California Department of Health Services and Impact Assessment Inc.

  27. 4. Breast milk - Methods Development • Important biological matrix to CA stakeholders • Supports related legislative initiatives • Lab studies proposal to develop high throughput method • Initial focus on persistent organic pollutants (POPs) A project of the California Department of Health Services and Impact Assessment Inc.

  28. CONCLUSIONS • Strong collaborators (CHARGE, CHAMACOS, GDB) • Epidemiology • Community Outreach • Samples • Balance community focus and normative data collection A project of the California Department of Health Services and Impact Assessment Inc.

  29. CONCLUSIONS • Lab methods • Organophosphates in urine • Persistent organic pollutants (POPs) in serum and breast milk • Mercury and Lead in blood • Multimetal screen • Phthalates in urine • Pyrethroids in urine • Institutionalize public health biomonitoring A project of the California Department of Health Services and Impact Assessment Inc.

More Related