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Short History of NIH

Short History of NIH. Victoria A. Harden, Ph.D. Historian, NIH. Federal Government and Medical Research. No support at all before late 19th century Medical system based on “humoral” theory U.S. Constitution made no mention of health or medicine. Marine Hospital Service.

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Short History of NIH

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  1. Short History of NIH Victoria A. Harden, Ph.D. Historian, NIH

  2. Federal Government and Medical Research • No support at all before late 19th century • Medical system based on “humoral” theory • U.S. Constitution made no mention of health or medicine

  3. Marine Hospital Service • Established in 1798 under the commerce clause of the Constitution • Series of hospitals for merchant seamen • Placed in Treasury Department to collect 20 cents per month from each sailor Marine Hospital, New Orleans, Louisiana

  4. Political Philosophy • Americans were suspicious of government funding because they believed: • If government funds research, government can control what research gets done. • People who accept funds from the government are not self-reliant.

  5. Discovery of Anesthesia • Only major U.S. contribution to medicine before the U.S. Civil War • Wholly in the private sector “The First Operation with Ether” by Robert Hinckley

  6. Louis Pasteur Robert Koch Intellectual Revolution, 1870s-1890s The Germ Theory

  7. The Power of the Germ Theory

  8. National Board of Health • First grants for medical research to university scientists • Bitter political disagreements • 1878-1883/93

  9. Marine Hospital, Staten Island, NY Joseph J. Kinyoun, M.D. Laboratory of Hygiene Marine Hospital Service

  10. Kinyoun’s laboratory Kinyoun’s microscope & first publication

  11. Growth of laboratory • 1891--moved to Washington, DC • 1894--production of diphtheria antitoxin begun • rabies vaccine, smallpox vaccine made available Diphtheria antitoxin made by Hygienic Laboratory, 1895

  12. 1902 Biologics Control Act • 1901: 13 children in St. Louis died from contaminated diphtheria antitoxin • 1902: Congress acted • Hygienic Laboratory given regulatory responsibility Mulford rabies vaccine outfit

  13. 1901 NIH’s organic legislation • Buried in a supplemental appropriations act • Authorized $35,000 to build one building • Authority to investigate “infectious and contagious diseases” 25th & E Sts, Washington, DC, 1904-1939/41 home of NIH

  14. 1902 Research Program Begins • New Name: Public Health and Marine Hospital Service • Hygienic Laboratory organized into 4 divisions • Pathology and Bacteriology (original work) • Zoology • Chemistry • Pharmacology • Ph.D.s hired to head new divisions

  15. 1912 Non-infectious disease research • New Name: Public Health Service • Hygienic Laboratory authorized to investigate noncontagious diseases and the pollution of waterways

  16. Who got pellagra? Dr. Joseph Goldberger Pellagra: niacin deficiency

  17. Who got hookworm? Dr. Charles Wardell Stiles Hookworm: parasitic helminth

  18. 1916First professional woman hired Dr. Ida Bengtson, Bacteriologist Worked in Biologics Control

  19. Charles H. Herty (Georgia and N.C.) Senator Joseph Ransdell (Louisiana) Ransdell Act, 1930Hygienic Laboratory renamedNational Institute of Health

  20. 1930sChange in Political Philosophy • Government “control” can be used to rectify injustices • Government “control” can provide oversight of ethics of research • Scientists can remain self-reliant if they decide which projects to undertake

  21. NCI created, NIH moved to Bethesda 1937--National Cancer Act • foreshadowed categorical structure • authorized to give grants and fellowships 1939-41--move from DC to Bethesda NIH Campus under construction, ca. 1939

  22. 1938-41 70 Acres for Science • Some opposition to construction from Bethesda Chamber of Commerce and Montgomery County Commission • October 31, 1940: FDR dedicated campus

  23. Sept. 1, 1939 June 1940 Sept. 1940 Germany invaded Poland Battle of Britain U.S. National Defense Council established Japan signed mutual assistance pact with Germany and Italy: global war Congress enacted firstpeacetime draft in US history Steps Toward War

  24. Health of Recruits • 43 percent unfit for military service • 28 percent not fit for any military service • 15 percent fit for limited service only NIH Division of Public Health Methods worked with the Selective Service

  25. Research for the home front:Workers protected • Dangers of specific munitions • Diagnostic tests for toxic materials Working conditions of >300,000 defense workers improved

  26. Exotic diseases Malaria Yellow fever Epidemic typhus Tsutsugamushi (scrub typhus) schistosomiasis Battlefield trauma Shock Burns Blood & blood products High altitude physiology Research for the battlefield

  27. Surgeon General Thomas Parran NIH Director Rolla E. Dyer Architects of today’s NIH World War II leaders

  28. 1944 PHS Act • Authorized NIH grants program • Authorized clinical research • Mandated materials prepared for public

  29. Rapid growth, 1945-2001 • 1945: NIH and NCI • 1949: 6 institutes • 1969: 15 institutes, centers & divisions • 1999: 25 institutes & centers • 2001: 27 institutes & centers

  30. NIH Clinical Center NIH Clinical Center, 1953 “Pool of Bethesda”

  31. Lorraine cross design philosophy • Goal: transfer new biomedical knowledge as rapidly as possible from the laboratory to the patient’s bedside

  32. Protection for Human Subjects • Hippocratic Oath: First, do no harm • Nazi medical experiments • Nuremberg Code (1946): Informed consent must be obtained • Clinical Center review of protocols, 1953 • Tuskegee syphilis study (begun 1932, recognized as public scandal 1972) • Protection for Human Subjects Act (1974): • Institutional Review Boards established • NIH Office of Protection from Research Risks established • Office of Human Research Protections, DHHS • established June 2000

  33. Major lines of research, 1945-2003: Human Genetics • http://history.nih.gov/exhibits/genetics/

  34. NIH and Genetics Research • 1961—Nirenberg broke genetic code • 1973—rDNA safety issues • Guidelines written • RAC established • 1988—Human Genome Project launched • 2003—Human Genome Project completed

  35. Major lines of research, 1945-2003:Basic Research • http://history.nih.gov/exhibits/bowman/

  36. NIH and Basic Research • >100 Nobel prizes, 5 intramural • Biochemical instrumentation, 1945-1968 • Molecular biology, 1970s-present • Neuroscience: emphasis on “brain” rather than “mind”

  37. Major lines of research, 1945-2003:Chronic Diseases • http://history.nih.gov/exhibits/opiates/

  38. NIH and Chronic Diseases • Drug addiction: search for “nonaddicting opiate” • Heart disease, stroke, sickle cell anemia • Cancer • Diabetes, types I and II • Arthritis

  39. Major lines of research, 1945-2003:infectious diseases • http://aidshistory.nih.gov/home.html

  40. NIH and infectious diseases • Surprising reappearance in 1981: AIDS • Emerging diseases: SARS, Ebola, hanta virus, etc. • Bioterror agents: anthrax, plague, smallpox, botulism, tularemia • Major world killers: malaria, rotavirus, polio

  41. NIH worldview: absorbing but dangerous.How do we deal with the brave new world?

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