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Sickle Cell Disease. Created by: Ryan Foreman and Evan Yavner Period 4 Mrs. Geithner - Marron February 2011. About Sickle Cell Disease. Sickle Cell Disease is a autosomal recessive blood disease The blood cells of someone with Sickle Cell Disease are shaped differently
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Sickle Cell Disease Created by: Ryan Foreman and Evan Yavner Period 4 Mrs. Geithner-Marron February 2011
About Sickle Cell Disease • Sickle Cell Disease is a autosomal recessive blood disease • The blood cells of someone with Sickle Cell Disease are shaped differently • This is a result of large amounts of hemoglobin A and S in these blood cells • These cells get stuck in tissues of the human body
How Sickle Cell Disease is inherited • When a person has the homozygous recessive trait (for example: rr or aa) • Some are carriers of Sickle Cell Disease, but it is not present in their blood cells • This would occur when someone has the heterozygous trait for the disease (for example Rr or Aa)
Sickle Cell Disease ratios • This disease is present in: -1 in 58,000 Caucasians -1 in 500 African-Americans -1 in 900 Hispanics -1 in 250,000 newly born babies • 1 in 12 African-Americans has the trait
Prognosis of Sickle Cell Disease • There is a high probability that patients with sickle cell disease will suffer from organ failure and infection • A common life expectancy of a man is 60 • A common life expectancy of a woman is 68
Sickle Cell Disease and African-Americans • Sickle Cell Disease is very common in African-Americans because it is protective against Malaria • This caused the development of the trait in areas where Malaria is common
Common symptoms of Sickle Cell Disease • Infection • Coughs and/or trouble breathing • Pale skin and/or lips • Yellowing of body • Crankiness, tiredness, or weakness • Vomiting • Swelling of body
Diagnosis of Sickle Cell Disease • Sickle Cell Disease is diagnosed through hemoglobin electrophoresis • The result is isolated samples of hemoglobin from the patients • A current is applied to a gel base where the blood is located • Depending on the type of hemoglobin, the sample will travel a specific distance
Treatment for Sickle Cell Disease • Primary treatment for Sickle Cell Disease is a bone marrow transplant • Bone marrow is taken from the donor and given to the patient with Sickle Cell Disease • This is the most efficient treatment because it purifies the source for the red blood cells
Other treatments Other treatments involve: • Blood transfusions • Cord blood stem cells • Gene therapy • Penicillin prophylaxis • There is currently no cure for Sickle Cell Disease • Scientists have been experimenting with stem cells
Works Cited Bojanowski, Jennifer. “Sickle Cell Disease.” Gale Encyclopedia of Medicine. 2005. Print. Jones, Phil. Genes and disease. New York: Chelsea house, 2008. Print. www.sicklecelldisease.org/about_sed/index.phtm. “Sickle cell bone marrow transplant best.” Sickle cell disease. ScienceOnline. (November 11 2008). Science Online. Web. 6 Feb 2011. Fofweb.com/science/default.asp?item10=we40. Sickle Cell Disease Association of America. What is Sickle Cell Disease?. Web. 30 Sept 2005. 2 Feb 2011. http://www.sicklecelldisease.org/about_scd/index.phtml. New Sickle-Cell therapy shows promise. Science Online. 9 December 2011. <http://www.fofweb.com/activelink2.asp?ItemId=WE40&SID=5&iPin=UPI-1- 20091209-154112-bc-us-sicklecell&SingleRecord=True>.
