1 / 7

Sir Hans Adolf Krebs Sheffield University United Kingdom

The Nobel Prize in Physiology or Medicine 1953. "for his discovery of co-enzyme A and its importance for intermediary metabolism". "for his discovery of the citric acid cycle” 1937. Sir Hans Adolf Krebs Sheffield University United Kingdom. Fritz Albert Lipmann Harvard Medical School

trudy
Download Presentation

Sir Hans Adolf Krebs Sheffield University United Kingdom

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. The Nobel Prize in Physiology or Medicine 1953 "for his discovery of co-enzyme A and its importance for intermediary metabolism" "for his discovery of the citric acid cycle” 1937 Sir Hans Adolf Krebs Sheffield University United Kingdom Fritz Albert Lipmann Harvard Medical School Boston, MA, USA At the University of Freiburg (1932), Krebs discovered (with the German biochemist Kurt Henseleit) a series of chemical reactions (now known as the urea cycle) by which ammonia is converted to urea in mammalian tissue;

  2. GLICOLISIcitoplasma CH3-CO~CoA (acetil ~ COA) mitocondrio

  3. Ciclo di Krebs o Ciclo degli acidi tricarbiossilici o Ciclo del citrato Via metabolica finale di - glucosio - acidi grassi - amminoacidi

  4. ANAEROBIOSI GLUCOSIO AEROBIOSI GLUCOSIO  2 PIRUVATO  2 ACETIL-CoA 2 ATP 2 LATTATO 2 ATP 5 ATP 2 NADH 5 ATP 2 NADH NADH + H+ 1 FADH2 1 GTP 7,5 ATP 1,5 ATP 1 ATP 2 x 2 x 20 ATP 10 ATP TOT 32 ATP

  5. piruvato principale via di entrata CO2 aspartato • BIOSINTESI LIPIDI • acidi grassi • - colesterolo BIOSINTESI GLUCOSIO BIOSINTESI UREA fenilalanina tirosina BIOSINTESI E CATABOLISMO AMMINOACIDI Val Ile Met glutammato BIOSINTESI EME - porfirina Ac grassi a catena dispari metab. extra epatico corpi chetonici

  6. acetil-CoA isocitrato (deidrogenasi) ossalacetato -chetoglutarato (deidrogenasi) malato (deidrogenasi) Inibita da NADH Inibita da succinil-CoA succinil-CoA Controllo: rapporto mitocondriale NAD+/NADH e stato energetico della cellula 3 deidrogenasi inibite da alti livelli NADH e bassi livelli di NAD+ Inibita da NADH Attivata da ADP Inibita dA NADH

More Related