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Cholera: Next Door?

Cholera: Next Door?. BioQUEST 2012. Module Design. Case Study Format Learning Objectives Resources Data Analysis & Visualization Tools Statistics Assessment. Learning Objectives:. In this module, students will:

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Cholera: Next Door?

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  1. Cholera: Next Door? BioQUEST 2012

  2. Module Design • Case Study Format • Learning Objectives • Resources • Data Analysis & Visualization • Tools • Statistics • Assessment

  3. Learning Objectives: • In this module, students will: • (1) investigate the natural history of Vibriocholerae, a pathogenic bacterium of global and historical significance. Use their knowledge of the organism’s biology to predict conditions favorable for epidemics. • (2) compare and contrast cholera outbreaks from multiple locations. Determine whether demographic, environmental, or other variables are associated with an epidemic’s magnitude of impact. • (3) model (or predict or explain) potential modes of disease transmission and/or dynamics of disease spread during an epidemic. • (4) improve foundational skills in: • searching and obtaining data available online; • evaluating quality of datasets from a variety of sources; and • interpreting, analyzing, and visualizing diverse types of data

  4. Online Resources: News & Media • http://www.catholic.org/international/international_story.php?id=44401&utm_source=catholic.org%2Fhomepage&utm_medium=banner&utm_content=latest%2Bnews - Catholic Online, posted 1/13/12 • http://www.nytimes.com/2012/01/10/health/haitian-cholera-epidemic-traced-to-first-known-victim.html?_r=1&scp=1&sq=cholera%20haiti&st=cse - discovery of first cholera case in Haiti, NYT 1/10/12 • http://www.npr.org/templates/story/story.php?storyId=144929218 - discovery of first cholera case in Haiti Natural history, symptoms, epidemiology, general information • http://www.who.int/mediacentre/factsheets/fs107/en/index.html - WHO • http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001348/ - PubMed Health • http://www.cdc.gov/cholera/general/ • http://www.cdc.gov/haiticholera/ - CDC

  5. Online Resources: Accounts, reports of outbreaks • http://www.who.int/csr/don/archive/disease/cholera/en/index.html - periodic updates about outbreaks globally Profiles of Countries with Cholera • http://www.who.int/cholera/countries/en/index.html - general information (geographic, economic, environmental) for countries with cholera in their histories Data • http://apps.who.int/ghodata/?vid=2250 - cases, deaths, fatality rates by country, year • http://www.who.int/cholera/statistics/en/index.html - articles compiled annually with raw data • http://www.who.int/gho/epidemic_diseases/cholera/en/index.html - maps with data for cases, fatalities • http://emergency.cdc.gov/situationawareness/haiticholera/data.asp - stratified by region and demographics

  6. Online Resources: Maps • http://gamapserver.who.int/mapLibrary/app/searchResults.aspx - WHO Cholera Map Library • http://emergency.cdc.gov/situationawareness/haiticholera/staticmaps.asp - multiple static maps (distribution of outbreaks, cumulative attack rates, etc) • http://gamapserver.who.int/gho/interactive_charts/cholera/atlas.html - interactive http://new.paho.org/hq/images/Atlas_IHR/CholeraHispaniola/atlas.html - interactive • http://www.bt.cdc.gov/situationawareness/haiticholera/Flash/bt/atlas.html - interactive, multiple filters and resolutions

  7. http://books.google.com/books?id=LIYaAAAAMAAJ&lpg=PA173&ots=3A_xyGSTMb&dq=Cholera%20epidemic%20map%20of%20Nashville%2C%20Tennessee%2C%201873%20%2F%20Ely%20McClellan.&pg=PP11#v=onepage&q&f=truehttp://books.google.com/books?id=LIYaAAAAMAAJ&lpg=PA173&ots=3A_xyGSTMb&dq=Cholera%20epidemic%20map%20of%20Nashville%2C%20Tennessee%2C%201873%20%2F%20Ely%20McClellan.&pg=PP11#v=onepage&q&f=true

  8. Cholera epidemic map of Nashville, Tennessee, 1873 / Ely McClellan. http://www.nlm.nih.gov/exhibition/cholera/images/a024226.jpg

  9. http://www.worldmapper.org/posters/worldmapper_map231_ver5.pdfhttp://www.worldmapper.org/posters/worldmapper_map231_ver5.pdf

  10. www.bit.ly/w6m9YO

  11. Pam American Health OrganizationInteractive map • http://new.paho.org/hq/images/Atlas_IHR/CholeraHispaniola/atlas.html

  12. Statistical Analysis • 1) Finding the “RIGHT” parameters • a) Sanitation • b) Population Density • c) Environmental Conditions • d) Non availability of Clean water • e) Limited Access to health care • f) General Awareness of disease spread • etc……..

  13. Crunching the Data • Approach • 1) Undergraduate Level • a) Study the data set • b) Descriptive statistics • c) Plot the data • d) Use Regression Approach • e) Find the optimal model • f) Run the model diagnostics

  14. Crunching the Data • Approach • 2) Graduate Level • a) All above • b) Non-normal distribution • c) Poisson Modeling • c) MLE approach • d) Bayesian Model • e) Find the optimal model • f) Run the model diagnostics

  15. Assessment • Pre/Post-Test Assessment • Learning & Thinking Skills • Presentations, Activities, Group Work • Science Process Skills • Solving problems, critical thinking, testing hypothesis • Attitudes Toward Science • Comfort & confidence • Module Content • Background info, mode of action & transmission, data analysis tools

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