1 / 9

Epigenetics

Epigenetics. Imprinting. For most genes, we inherit two working copies -- one from mom and one from dad But with imprinted genes, we inherit only one working copy. Depending on the gene, either the copy from mom or the copy from dad is epigenetically silenced.

tymon
Download Presentation

Epigenetics

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Epigenetics

  2. Imprinting • For most genes, we inherit two working copies -- one from mom and one from dad • But with imprinted genes, we inherit only one working copy. • Depending on the gene, either the copy from mom or the copy from dad is epigenetically silenced. • Silencing usually happens through the addition of methyl groups during egg or sperm formation. • epigenetic tags on imprinted genes usually stay put for the life of the organism. • they can be reset during egg and sperm formation. http://learn.genetics.utah.edu/content/epigenetics/imprinting/

  3. Soon after egg and sperm meet, most of the epigenetic tags that activate and silence genes are stripped from the DNA.

  4. About 156 genes are imprinted in mammals. • Approximately 88 of these are active (expressed) on the maternally inherited chromosome. • Approximately 68 of these are active (expressed) on the paternally inherited chromosome.

  5. In fact, these particular gene pairs MUST be monoallelicin order for normal embryo development to occur.

  6. “Normal” chromosome 15

  7. Prader-Willi Syndrome

  8. Angelman Syndrome

More Related