1 / 9

Hypothermic machine perfusion improves outcomes in DCD kidneys

Hypothermic machine perfusion improves outcomes in DCD kidneys. L. Szabo P. Laftsidis E . Ablorsu Cardiff Transplant Unit Cardiff UK. _________. Background. Aim. To assess the effect of hypothermic pulsatile machine perfusion (MP) on the early function of DCD kidneys

vernon
Download Presentation

Hypothermic machine perfusion improves outcomes in DCD kidneys

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Hypothermic machine perfusionimproves outcomes in DCD kidneys L. Szabo P. LaftsidisE. Ablorsu Cardiff Transplant Unit Cardiff UK

  2. _________ Background

  3. Aim • To assess the effect of hypothermic pulsatile machine perfusion (MP) on the early function of DCD kidneys • To evaluate the correlation between perfusion parameters and early graft function

  4. Method • Prospective, non-randomized observational study • From 1 Jan 2010 to 10 June 2013 • 155 consecutive DCD kidney transplants • Excluded • Double kidney transplants • Kidney-pancreas transplants • Assessed parameters • Donor age, CIT, type of storage (MP v CS) • Outcomes • eGFR @ 1 month • Functional DGF

  5. Results

  6. results

  7. Regression analysis • Donor age, CIT and type of storage correlated with fDGF • @ 1, 3 and 6 months donor age, CIT, and type of storage showed significant correlation with the eGFR. • @1 and 2 years only the donor age correlated significantly with the eGFR. • Perfusion parameters, CIT and starting resistance were found to correlate significantly with DGF (Exp(B)=1.17 and 21.26 respectively, p=0.05)

  8. Survival

  9. Conclusion • MP, on DCD kidneys, can neutralize the adverse effect of the long CIT, • leading to at least equivalent early graft function (GFR), • Start resistance correlates with DGF. • No difference in long term function and survival.

More Related