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The Superpower of Not Feeling Pain: The Enigma of Congenital Insensitivity to Pain with Anhidrosis (CIPA)

Delve into the intriguing world of CIPA, a rare autosomal recessive disorder causing the inability to feel pain. Explore the genetic mutation, impact on nociceptors, and the unique challenges faced by individuals with this condition.

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The Superpower of Not Feeling Pain: The Enigma of Congenital Insensitivity to Pain with Anhidrosis (CIPA)

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  1. Não sentir dor = super poder?

  2. Nociceptor: ponta de terminacoes nervosas livres no tecido >>> alto grau de excitabilidade • Tipos de Nociceptor: • Amielinicos:transmissão lenta do impulso elétrico >>> dor fraca • Mielinicos: transmissão rápida do impulso elétrico >>> dor aguda

  3. VIDEO

  4. CIPA • CIPA: Congenital Insensitivity to Pain with Anhidrosis (ICAD: Insensibilidade Congênita a Dor) • Doença recessiva autossomica muito rara Mutação no cromossomo 1 100 casos documentados no mundo • Mutação no gene TRKA- NGF

  5. CIPA TRKA + NGF = Sobrevivência dos Nociceptores TRKA defeituosa não tem afinidade com NGF = Morte dos Nociceptores >>> CIPA As mensagens de dor não chegam ao cerébro, porque ninguém as envia.

  6. CIPA • Anhidrosis: Anidrose • TRKA defeituosa - Falta de inervação na epiderme e nas glândulas sudoríparas écrinas; - Não há regulação de temperatura através do suor >>> febre constante

  7. Bibliografia • http://saude.hsw.uol.com.br/cipa2.htm • http://www.nature.com/embor/journal/v3/n4/images/embor178-f2.jpg • http://meducator.org/index.php/Issue-6-April-2005/Congenital-Insensitivity-to-Pain-with-Anhidrosis-CIPA.html • http://www.medicalnewstoday.com/articles/42140.php

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