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iBSc: Question 5

iBSc: Question 5. By Alan McLeod. Getting the best marks. Read the whole question – a latter section may give you a clue about an earlier one. To see how many points you need look at the marks allocated – for example a 3 point question is generally looking for 3 salient points

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iBSc: Question 5

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  1. iBSc: Question 5 By Alan McLeod

  2. Getting the best marks Read the whole question – a latter section may give you a clue about an earlier one. To see how many points you need look at the marks allocated – for example a 3 point question is generally looking for 3 salient points If giving a list answer put the best answers first – examiners will not usually mark answers too far down a list Always write something – it may get you part of a mark and is anonymised so no one will think you are stupid! If you genuinely have no clue then re-write the question to see if this sparks some ideas. If not then move on and come back at the end. And remember – always write something. Good luck!

  3. Question 5 Mrs McCartney, a 52 year old woman has been getting pains in her finger joints. She think it may be ‘arthritis, like my mum had’ Q5.1 • Outline the gate-control theory of pain (6) Q5.2 • Compare rheumatoid and osteoarthritis in terms of the joints affected (5)

  4. Question 5 This disease affects synovial joints Q5.3 • What part of the joint does Rheumatoid arthritis affect (1) Q5.4 • Draw and label a synovial joint (5)

  5. Question 5 One of the essential components of a synovial joint is cartilage which is made from collagen Q5.5 • Describe how collagen is formed (8)

  6. Question 5 The pain is inflammatory in cause in rheumatoid arthritis Q5.7 • List four other symptoms / signs of inflammation (2)

  7. Question 5 Rheumatoid factor has prognostic value in patients with rheumatoid arthritis. It is an antibody against the Fc portion if IgG Q5.8 • Draw and label the structure of an IgG molecule including the Fc portion (6)

  8. The Answers View these on ‘note view’ rather than on full screen – additional notes are provided for some slides

  9. Gate Control Theory Meds Ab Ad, C Anxiety Worry Depression Etc. Happiness Optimism Relaxation Etc.

  10. Gate Control Theory vb BRAIN vb vb vb Red: Ad/C ‘small’ fibre Black: Ab ‘large’ fibre Blue: Interneurone Yellow: Projection neurone

  11. Opening and Closing the Gate

  12. Osteo and Rheumatoid Osteoarthritis • Disease of cartilage • No immune component • M=F • Rheumatoid factor -ve • Assymetric joints • Large > small joints • DIP Joints Rheumatoid arthritis • Disease of synovium • Autoimmune • M<F (approx 1 : 3-4) • Rheumatoid factor 80% • Symmetrical • Small > large joints • MCP + PIP Joints

  13. Synovial Joint Video Link

  14. CollagenSynthesis http://depts.washington.edu/bonebio/ASBMRed/collagen/collagen.swf

  15. Inflammation Features • Rubor (redness) • Calor (heat) • Dolor (pain) • Tumor (swelling) • Loss of Function

  16. IgG Variable region FAB Light chain Hinge region Heavy chain Fc

  17. The End The slides here should allow you to mark your own work – remember 1 mark per answer* up to the maximum for the question. Multiply by 3 to get percentage points. I assume a 60% pass mark. Sorry but I am unable to give further advice on answers due to time constraints.

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