1 / 9

M ultiscale modelling to predict the risk of osteoporotic bone fractures

M ultiscale modelling to predict the risk of osteoporotic bone fractures. VPHOP Integrated project. Osteoporosis is a killer. OP fractures kill as many women as breast cancer 30 to 50% of all women and 15 to 30% of all men will face an osteoporotic fracture in their lifetime

vivi
Download Presentation

M ultiscale modelling to predict the risk of osteoporotic bone fractures

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Multiscale modelling to predict the risk of osteoporotic bone fractures VPHOP Integrated project

  2. Osteoporosis is a killer • OP fractures kill as many women as breast cancer • 30 to 50% of all women and 15 to 30% of all men will face an osteoporotic fracture in their lifetime • 4,000,000 fractures every year cost Europe €30,000,000,000 • Forecast to double by 2050 • 250,000 elders will die of related complications within 12 months, all others will remain impaired

  3. The VPHOP Consortium • 21 partners • 7 industrial partners • 5 clinical centres • Research leaders in: Biomechanics, biomaterials, computer sciences, biomedical informatics, mechanobiology, CAS, technology assessment, medical imaging & instrument.

  4. EOSTM Dual Energy system • Scanning area: 5-175 cm (sitting - upright) • Sim. bi-planar acquisition, 20 s, head-to-toe • Low dose (÷ 10 vs. film/screen) • 3D reconstruction of ext. geometry • Bi-planar DXA

  5. Actibelt® • 3D accelerometer integrated in belt buckle • Objective measurement of neuromuscular condition during ambulatory visit • Monitoring long term activity (5 days)

  6. Organ-level Model Personalised risk of fracture Clinical workflow Constitutive Equation Loading spectrum Tissue-level Model Disease & pharma (pre-computed) Effect of augmentation Body-level Model Bone Remodelling Model Augmentation Model

  7. VPHOP PR(t) curve [predicted]

  8. Disclaimer • VPHOP is a project co-funded by the European Commission Seventh FRAMEWORK PROGRAMME • The research reported upon in this presentation has either directly or indirectly been supported by the European Commission, Directorate General Information Society and Media, Brussels. • The results, analyses and conclusions derived there from reflect solely the views of its authors and of the presenter. • The European Community is not liable for any use that may be made of the information contained therein.

More Related