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Nov 20, 2014

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S á nchez-Serrano Nature Reviews Drug Discovery 5 , 107 – 114 (February 2006) | doi:10.1038/nrd1959.

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nrd1959 pf1

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Sánchez-Serrano Nature Reviews Drug Discovery5, 107–114 (February 2006) | doi:10.1038/nrd1959

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Figure 1 Radiographic changes to melanoma metastases in the brain with administration of CTLA-4 blockade. Hodi FS et al . (2008) CTLA-4 blockade with ipilimumab induces significant clinical benefit in a female with melanoma metastases to the CNS Nat Clin Pract Oncol doi:10.1038/ncponc1183.

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Figure 1 Mechanisms by which aldosterone and/or MR activation induce oxidative stress, inflammation, and fibrosis. Brown, N. J. (2013) Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis Nat. Rev. Nephrol. doi:10.1038/nrneph.2013.110.

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Figure 1 Comparison of a | PFS and b | overall survival curves from the JGOG study on dosedense therapy 1 and the GOG study on IP therapy. Thomas Hogberg (2010) Current drugs still have potential in advanced ovarian cancer Nat. Rev. Clin. Oncol. doi:10.1038/nrclinonc.2010.37.

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Figure 1 World map indicating developing countries as classified by World Bank criteria in color and relating latitude by geographic regions to skin ability to synthesize vitamin D as estimated from information provided in an article by Tavera-Mendoza and White.

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Figure 1 Correlation between testosterone plasma levels and different clinical, instrumental and sexual parameters. Corona, C. & Maggi, M. (2009) The role of testosterone in erectile dysfunction Nat. Rev. Urol. doi:10.1038/nrurol.2009.235.

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Figure 1 Whole-body positron emission tomography scan showing a small glucose-avid lesion in the pelvis just superior to the bladder in the region of the left adnexa. Santillan A and Bristow RE (2006) Paraneoplastic cerebellar degeneration in a woman with ovarian cancer

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Figure 1 Renal survival of patients in our study with pauci-immune crescentic glomerulonephritis with and without ANCAs. Permission obtained from the American Society of Nephrology  Chen, M. et al. Antineutrophil cytoplasmic autoantibody negative pauci-immune crescentic glomerulonephritis.

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Figure 1 CT scan of tumor progression showing enlarged right laterocervical lymph nodes (white arrows) and laryngeal tumor (black arrows). Ares C and Allal AS (2005) Long-term complete remission of laryngeal Kaposi's sarcoma after palliative

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Figure 1 The products of two genes are required to reconstitute basic telomerase activity; the RNA component, hTR, which includes the template for synthesis of telomere DNA, and the protein catalytic component, hTERT, which has reverse transcriptase activity.

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FIGURE 1 Localization of potential relevant molecular targets in irritable bowel syndrome with the specific classes of agents discussed in this Review. Cremonini F and Talley NJ (2005) Treatments targeting putative mechanisms in irritable bowel syndrome

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Figure 1 Postpartum contrast-enhanced helical chest CT scan showing an enlarged internal mammary lymph node (white arrow). Matthew S Katz et al . (2005) Palpable right breast mass in a pregnant woman . Nat Clin Pract Oncol 2 : 218 – 221 10.1038/ncponc0135.

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Figure 1 Minor salivary gland biopsy, stained with hematoxylin-eosin, from a patient with Sj ö gren's syndrome. Nordmark G et al. (2006) Mechanisms of Disease: primary Sj ö gren's syndrome and the type I interferon system Nat Clin Pract Rheumatol 2: 26 2 – 269 doi:10.1038/ ncprheum0173.

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Figure 1 Combination treatment schema for patients with rectal cancer enrolled in a clinical trial. Willett CG et al . (2007) Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer Nat Clin Pract Oncol 4 : 316 –321 doi:10.1038/ncponc0813.

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Figure 1 Results of cardiac function tests in the phase III trial of lapatinib plus capecitabine for metastatic breast cancer. Permission obtained from Geyer CE et al . (2006) Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 355: 2733–2743.

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Figure 1 Schematic of oncolytic virotherapy mechanism of action: viral replication, cell killing, virus release and spread within cancer tissue but not normal tissues.

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Figure 1 Images of the case patient with an interstitial deletion of 5q22 encompassing the APC (adenomatous polyposis coli) gene, taken at 22 years of age. Heald B et al. (2007) Familial adenomatous polyposis in a patient with unexplained mental retardation

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Figure 1 The principal source of renal dopamine is circulating L -DOPA, which is freely filtered by the glomerulus.

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Figure 1 Forrest plot showing pooled data for a | incidence of clinical fractures and b | incidence of breast cancer recurrence from the Z‑FAST, ZO‑FAST and EZO‑FAST studies.

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Figure 1 Statistical power of the DIAGRAM meta-analysis ( n = 9,562) to detect diabetes-related variants of different ORs across various risk allele frequencies, assuming complete coverage.

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Figure 1 Infection with JC virus is at first asymptomatic and presumably occurs at an early age by oral route. Calabrese, L. H. et al. (2014) Sorting out the risks in progressive multifocal leukoencephalopathy Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2014.167.

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Figure 1 Upstream determinants (genes and molecular pathology) and downstream effects (clinical phenotypes) for the main neurodegenerative disorders. Pievani, M. et al. (2014) Brain connectivity in neurodegenerative diseases—from phenotype to proteinopathy

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Figure 1 Opposing association between lower-body fat accumulation and metabolically healthy obesity. Karpe, F. & Pinnick, K. E. (2014) Biology of upper-body and lower-body adipose tissue—link to whole-body phenotypes Nat. Rev. Endocrinol. doi:10.1038/nrendo.2014.185.

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