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Investigation of Bubble Formation in Tuohy-Borst Adaptors

Study the cause and solution for bubbles in medical adaptors that can cause strokes, focusing on fluid dynamics and system improvements.

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Investigation of Bubble Formation in Tuohy-Borst Adaptors

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  1. Investigation of Bubble Formation in Tuohy-Borst Adaptors Department of Biomedical Engineering Melanie Bernard, Isaac Clements, & Jason Hirshburg Advisor: Ted Larson III, M.D. BME 272/273

  2. Problem Statement • Bubbles are seen within the Tuohy-Borst Adaptor • Can get stuck in small arteries in brain, inhibiting the supply of blood and oxygen • Causes stroke and death • Once present, bubbles are difficult to remove because they stick to inner surface of system • Occurs in adaptors of different geometries http://www.cookurological.com/products/ureteroscopy BME 272/273

  3. Problem Definition • Constraints • Solution must apply to all adaptor types • Any system changes must not significantly change adaptor cost or the catheterization procedure. • Must eliminate problem without having other detrimental effects. • Limitations • Time • Money • Equipment www.urmc.rochester.edu/strong/ cardio/cathlab.htm BME 272/273

  4. Background • Dr. Larson has 15 years of experience in interventional neuroradiology • Catheters uses: • Angiography • Embolization of arteriovenous fistulas • Aneurysms • Preoperative embolization of neck and intracranial tumors www.angiodynamics.com BME 272/273

  5. Primary Objective • Our task is to discover the cause of bubble formation and correct it • Observations: Bubbles… • Up to 10-20% of tube diameter • Stick to inner surface of adaptor • Appear at the edge of the Y-junction • Occur before microcatheter is inserted • Typically occur when catheter flow is reversed and blood hits the edge of the Y-junction and interfaces with the saline (or contrasting agent) BME 272/273

  6. Market Potential • Target group • Operating rooms worldwide • Will meet customer needs • Catheterization procedures will be safer • Is technologically feasible • Physical principles can be changed to eliminate bubble formation • Is economically viable • Adaptor costs should not rise after our design changes BME 272/273

  7. Previous Work • Observed device in a medical procedure on 11/18/03 • Literature Search • Innovation WorkBench • Conducted flow experiments with colored water and actual adaptor and tubing. • Observed device in a second medical procedure on 2/2/04 and obtained new supplies BME 272/273

  8. Previous Experiments : Results • Observed lots and lots of bubbles already present throughout the system! BME 272/273

  9. Current Work • Analyze results from previous experiments • Revise the experimental setup and procedure BME 272/273

  10. Future Work • Conduct revised experiments • Simulate actual pressures • ~100 over 60 mmHg for blood pressure • 250 mmHg for the saline • Investigate effects of leaks • Simulate actual temperatures • Body temperature for the blood • Room temperature for the saline • Simulate blood properties • If animal blood is not feasible use a substitute of similar properties • Investigate properties of glycerin • Software models of fluid flow, using Computational Fluid Dynamics (CFD) software. www.ent.ohiou.edu/ ~mehta/cfd.htm BME 272/273

  11. Questions…? Visit our website at http://vubme.vuse.vanderbilt.edu/srdesign/2003/group17/ www.cookurological.com/.../ureteroscopy/ 5_06/5_06_06.html BME 272/273

  12. Acknowledgements We would like to thank the following professionals and experts for their input: Dr. Ted Larson and staff Dr. Paul King Dr. Joan Walker Dr. Robert Roselli Dr. Todd Giorgio Dr. Cynthia Paschal Dr. Rick Haselton Dr. Bob Galloway BME 272/273

  13. Bibliography • http://www.cookurological.com/products/ureteroscopy/5_06/5_06_06.html • http://www.angiodynamics.com/tips.htm • http://www.fda.gov/ohrms/dockets/ac/03/briefing/3993b1_CLiRpath-peripheral-IFU-revE-10.pdf BME 272/273

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