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Adult Immunization 2010 Hepatitis A Vaccine Segment

Adult Immunization 2010 Hepatitis A Vaccine Segment. This material is in the public domain This information is valid as of May 25, 2010. Hepatitis A. Fecal-oral transmission Indistinguishable from other types of hepatitis Does not lead to chronic infection

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Adult Immunization 2010 Hepatitis A Vaccine Segment

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  1. Adult Immunization 2010 Hepatitis A Vaccine Segment This material is in the public domain This information is valid as of May 25, 2010

  2. Hepatitis A • Fecal-oral transmission • Indistinguishable from other types of hepatitis • Does not lead to chronic infection • Complications related to the acute disease

  3. Hepatitis A Vaccines • Inactivated whole virus • HAVRIX • VAQTA • Single dose with a booster dose 6 to 18 months after the first dose • Supplied as a liquid in prefilled syringes and single dose vials

  4. Twinrix • Hepatitis B (adult dose) and hepatitis A (pediatric dose) • 3-dose series at 0, 1, 6 to12 months • 4-dose series at 0, 7, 21 to 30 days, booster at 12 months • Approved only for adults 18 years of age and older

  5. Schedules That Include BothTwinrix and Hepatitis A Vaccine • Adult formulation single-antigen hepatitis A vaccine may be used to complete a schedule begun with Twinrix and vice versa • Acceptable schedules • 2 Twinrix and 1 hepatitis A • 1 Twinrix and 2 hepatitis A • Maintain spacing recommended for Twinrix • 1 month between doses 1 and 2 • 5 months between doses 2 and 3

  6. Hepatitis A VaccineRecommendations • International travelers • Men who have sex with men • Injection and noninjection drug users • Persons with occupational risk (limited to certain laboratory personnel and animal handlers) • Persons with chronic liver disease MMWR 2006;55(RR-7)

  7. Hepatitis A VaccineRecommendations • All previously unvaccinated persons who anticipate close personal contact with an international adoptee from a country of high or intermediate endemicity during the first 60 days following arrival of the adoptee in the United States • The first dose should be administered as soon as adoption is planned MMWR 2009;58(36):1006-7

  8. Hepatitis A VaccineInternational Travel • The first dose of hepatitis A vaccine should be administered as soon as travel is considered • For healthy persons 40 years of age or younger: • 1 dose of single-antigen vaccine administered at any time before departure • Persons at risk of severe disease from hepatitis A virus planning to travel in 2 weeks or sooner should receive the first dose of vaccine and also can be administered immune globulin MMWR 2007;56(41):1080-4

  9. Hepatitis A Postexposure Prophylaxis • For healthy persons 12 months through 40 years of age: • single-antigen hepatitis A vaccine should be administered as soon as possible after exposure • For persons older than 40 years: • immune globulin is preferred • vaccine can be used if IG cannot be obtained MMWR 2007;56(41):1080-4

  10. Hepatitis A VaccineContraindications and Precautions • Severe allergic reaction to a vaccine component or following a prior dose • Moderate or severe acute illness MMWR 2006;55(RR-7)

  11. Hepatitis A VaccineAdverse Reactions • Local reactions 20%- 50% • Systemic reactions (fever, malaise) <10% • No serious adverse reactions reported MMWR 2006;55(RR-7)

  12. National Center for Immunization and Respiratory DiseasesContact Information • Telephone (800) CDC-INFO • Email nipinfo@cdc.gov • Website http://www.cdc.gov/vaccines/ • Broadcast Updates and Resources Web Page http://www.cdc.gov/vaccines/ed/webcasts.htm

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