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1,25 OH 2 D 3

7-dehydrocolesterol. Dieta/suplementos. P. MAKP/ CYP27B1. mKlotho. Luz UV-Piel. PTH. Colecalciferol (Vitamina D3). 1,25 OH 2 D 3. (Acciones endocrinas) Absorc intestinal Ca y P Reabsorcion Ca renal Regulacion PTH. Prostata,colon, Piel,Celulas inmunes. Calcidiol 25(OH) D3.

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1,25 OH 2 D 3

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  1. 7-dehydrocolesterol Dieta/suplementos P MAKP/ CYP27B1 mKlotho Luz UV-Piel PTH Colecalciferol (Vitamina D3) 1,25 OH2D3 • (Acciones endocrinas) • Absorc intestinal Ca y P • Reabsorcion Ca renal • Regulacion PTH Prostata,colon, Piel,Celulas inmunes.. Calcidiol 25(OH) D3 24-hidroxilasa Cyp24 (-) (a) FGFR FGF23 Osteocito 1,25 OH2D3 mKlotho Cyp271 Complejo 1,25 OH2D3 - VDR 1 alfaHidroxilasa 1,25 OH2D3 Acciones Autocrinas/paracrinas • Proteccion Renal • Efectos antirproteinuricos • Aumento de expresion de Nefrina • Inactivacion de NFkB • Proteccion Cardiovascular • Inhibicion SRAA • Regulacion ANP • Inhibicion proliferacion celulas • musculares lisas • Control de sistemica inflamacion • InhicionTh1 • Activacion Th2 • Induccion de CD4+CD25+ • Regulacion de Apoptosis (b) Hiperfosfaturia Klotho-FGF23 Disfunción endotelial (c) Fig. 1

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