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401 enrolled patients (JMTO LC00-03)

401 enrolled patients (JMTO LC00-03). 109 screened patients (BRI LC03-01). 201 patients randomly assigned to VGD group (JMTO LC00-03). 200 patients randomly assigned to PC group (JMTO LC00-03). 53 patients (BRI LC03-01). 56 patients (BRI LC03-01). 14 patients excluded due to not

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401 enrolled patients (JMTO LC00-03)

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  1. 401 enrolled patients (JMTO LC00-03) 109 screened patients (BRI LC03-01) 201 patients randomly assigned to VGD group (JMTO LC00-03) 200 patients randomly assigned to PC group (JMTO LC00-03) 53 patients (BRI LC03-01) 56 patients (BRI LC03-01) 14 patients excluded due to not informed consent 14 patients excluded for study 1 with other malignancy 2 with withdrawal of consent 11 with not informed consent 39 enrolled patients 42 enrolled patients 5 patients excluded from analysis 1 patient had no baseline QOL data 1 patient had only undergone the first cycle of chemotherapy 3 patients had no follow- up data 8 patients excluded from analysis 1 patient had no baseline QOL data 1 patient had no follow- up data 2 patients had only undergone the first cycle of chemotherapy 4 patients not calculated QOL score 34 patients included in analysis 34 patients included in analysis

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