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Kanal Ion Natrium

Kanal Ion Natrium. KELOMPOK 1 Nurina Khimatus S (G1F011022) Ruth Febrina (G1F011006) Dedah Nurhamidah (G1F011008) Inas Ghausani (G1F011012) Khilman Husna (G1F011036) Windhiana Sapti (G1F011038) Muhammad Rifki Hadafi (G1F011042) Vidya Nur A (G1F011048) Aisyah Putriani (G1F011050).

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Kanal Ion Natrium

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  1. Kanal Ion Natrium KELOMPOK 1 Nurina Khimatus S (G1F011022) Ruth Febrina (G1F011006) Dedah Nurhamidah (G1F011008) Inas Ghausani (G1F011012) Khilman Husna (G1F011036) Windhiana Sapti (G1F011038) Muhammad Rifki Hadafi (G1F011042) Vidya Nur A (G1F011048) Aisyah Putriani (G1F011050)

  2. Kanal Ion Na+ 4 domain 6 segmen sensor voltase membran α Subunit Kinetika aktivasi & inaktivasi β1 β domain trans membran tunggal Efisiensi kerja kanal β2

  3. Mekanisme Aksi Potensial Resting Potential : Keadaan istirahat dimana saraf tidak sedang menjalankan rangsang Depolarisasi: Peristiwa berkurangnya perbedaan polaritas (Ion Na+ masuk) Repolarisasi : Potensial aksi kembali ke keadaan semula (Ion K+ masuk) Hiperpolarisasi : peristiwa meningkatnya perbedaan polaritas (kanal ion K+ terbuka dan ion K keluar atau saat ion Cl- masuk ke dalam sel)

  4. antiepilepsi Kanal ion Na terbuka Masuk ion Na kesyaraf Peningkataneksibilitasselsyaraf FENITOIN DAN KARBAMAZEPIN Kanal ion aktif Kanal ion inaktif Ion Na diekstrasel Ion Na diintrasel Ion Na masukkeselsyaraf Kanal ion Na tertutup Potensialselmeningkat Kanal ion K terbuka Hiperpolarisasiataupenurunaneksitabilitassel

  5. Kanal Na+sebagai target aksiobatAntiaritmia Disopiramida, Ajmalin, Prokainamida Kelistrikan Kanal Na+ di nodussinoatrialdiblokadedepolarisasihiperpolarisasitidakadakelistrikan di jantungkontraksijantungberkurang Kanal Na+ sarafsimpatikdihambatdepolarisasi Hiperpolarisasiimpulssaraftidaktersampaikan Kontraksijantungberkurang Saraf

  6. Anastetik Lokal (Lidokain)

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