120 likes | 275 Views
Women with gynecologic or breast malignancies Navo et al. J Clin Oncol 2004 To tell or not to tell?. 53% of CAM users discussed using CAM therapy with a healthcare professional, most commonly their oncologist (56%) 63-74 % felt positive about discussing CAM
E N D
Women with gynecologic or breast malignancies Navo et al. J Clin Oncol 2004 To tell or not to tell? 53%of CAM users discussed using CAM therapy with a healthcare professional, most commonly their oncologist (56%) 63-74 % felt positive about discussing CAM Of those who did not discuss CAM the most common reason was “We were not asked”
Why discuss CAM in cancer treatment ? Efficacy Safety Demand Does it work? Is it safe? Do patients use it? Why? Eran Ben-Arye M.D.
Camptothecin Etoposide Camptotheca acuminata Podophyllum peltatum Do herbs possess anti-cancer properties? Efficacy Taxol Vincristine/ Vinblastine Madagascar periwinkle Taxus brevifolia Eran Ben-Arye M.D.
Safety Does CAM treatment involve risk? Eran Ben-Arye M.D. Side effects Drug-herb interactions Risk of under-treatment
Eran Ben Arye "שתה אותי" והיא לא שכחה לרגע, שאם שותים הרבה מבקבוק המסומן ב"רעל", קרוב לוודאי שיזיק לך, במוקדם או במאוחר
Hope with eight herbs Prostate cancer PC-SPES Eran Ben Arye
האם קיים קשר סיבתי בין שימוש בקאווה ופגיעה כבדית? טיפות חרדה Eran Ben-Arye M.D. The complementary & traditional medicine unit
Efficacy along the continuum Safety “Guilty until proven otherwise” Respect and Suspect Natural equals safety “if would not benefit, at least would do no harm”
Herbs and Supplements in the context of Nutrition Pharmacology Philosophical medical system Eran Ben-Arye
Herbs and food in Breast cancer prevention (?) Seaweed Laminaria Green tea Eran Ben-Arye M.D. The complementary & traditional medicine unit As treatment? p.o. 12 patients with ovarian & breast CA (France) Soy Bromelain
Green tea Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions. Korea. Eur J Cancer Prev 2003 Green tea extracts (ointment or capsule) in patients with HPV infected cervical lesions RCT 51 pts. Vs. 39 chronic cervicitis, Mild, moderate and severe dysplasia 69% response rate (35/51) Vs. 10% response rate (4/39) in untreated controls P<0.05
A randomized, double blind, Phase III trial using oral beta-carotene supplementation for women with high-gradeCIN USA. Cancer Epidemiol Biomarkers Prev 2001 In conclusion: Beta-carotene does not enhance the regression of high-grade CIN, especially in HPV-positive subjects Eran Ben-Arye M.D. The complementary & traditional medicine unit Oral folic acid supplementation for cervical dysplasia. USA. Am J Obstet Gynecol 1992 In conclusion: Folate deficiency may be involved as a carcinogen during the initiation of cervical dysplasia, but folic acid supplements do not alter the course of established disease