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RNA trafficking and translation in neurons John Carson

RNA trafficking and translation in neurons John Carson. PSD and RNA granule constitute a bipartite positive feedback system to convert ephemeral electrical stimulation at the synapse into enduring biochemical changes in the spine. postsynaptic density. PKM . MAP1B. ARC. MAP2. signaling.

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RNA trafficking and translation in neurons John Carson

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  1. RNA trafficking and translation in neurons John Carson

  2. PSD and RNA granule constitute a bipartite positive feedback system to convert ephemeral electrical stimulation at the synapse into enduring biochemical changes in the spine postsynaptic density PKM MAP1B ARC MAP2 signaling synthesis RNA granule RNA granule NG FMRP CaMKII TOG hnRNP A2 RNA FMRP

  3. translational output from individual RNA granules is bursty DHPG MAP1B PKM ARC MAP2 NG FMRP CaMKII

  4. Stochastic simulation of bursty translation requires initiation rates > 0.3/s A2RE protein

  5. intact TOG protein is necessary and sufficient for granule assembly and bursty translation D1 D2 D3 D4 D5 D6 D7 fast slow MAP1B PKM ARC MAP2 NG FMRP CaMKII TOG is a structural catalyst for translation

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