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F A C U L T Y O F H E A L T H A N D M E D I C A L S C I E N C E S U N I V E R S I T Y O F C O P E N H A G E N. Long term psychosocial consequences of false positive results in the Danish lung cancer CT-screening trial: a cohort study.
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F A C U L T Y O F H E A L T H A N D M E D I C A L S C I E N C E S U N I V E R S I T Y O F C O P E N H A G E N Long term psychosocial consequences of false positive results in the Danish lung cancer CT-screening trial: a cohort study Jakob F Rasmussen, Volkert Siersma, John Brodersen The Research Unit for General Practice and Section of General Practice, University of Copenhagen • Aim • To analyse the psychosocial consequences of participants receiving false-positive results in the Danish lung cancer CT-screening trial (DLCST). • Conclusion • False-positive results cause long term psychosocial consequences in the outcomes: Selfblame, Focus on airway symptoms, Harm of smoking and Regretful of still smoking. • Short term psychosocial consequences were found in the outcomes: Anxiety, Dejection, Existential values, Calm/Relaxed • Background • Participants in existing screening programmes receiving false-positive results experience psychosocial consequences. Lung cancer CT screening might also have psychosocial consequences for participants receiving false-positive results. • Method • DLCST was a randomised controlled lung cancer CT-screening trial offering the CT group five annual CT scans. • The questionnaire, consequences of screening –lung cancer, (COS-LC), was developed and validated to measure psychosocial consequences of participants in lung cancer CT-screening. • Participants receiving abnormal results were included and each participant was matched with participants receiving normal CT-screening results and participants from the control group. • The questionnaire COS-LC was completed at 5 time points: baseline, 1 week,1, 6 and 18 months after screening. Study design: The distribution of CT-screening results and the final diagnosis among the matched participants and the questionnaire response rate at 5 time points: baseline, 1 week, 1, 6, and 18 months after screening. Figure 1: The mean score of each of the 9 psychosocial outcomes of the questionnaire COS-LC part I (relevant for all screening trial participants) at 5 time points: baseline, 1 week, 1, 6 and 18 months after screening. • Results • Participants receiving false-positive results experience both short term and long term psychosocial consequences (figure 1 and 2). Presenting author: JakobFraes Rasmussen e: jakobra@sund.ku.dk m: +45 50998393 Figure 2. The mean score of each of the 6 psychosocial outcomes of the questionnaire COS-LC part II (only relevant for participants receiving final screening results) at 3 time points: 1, 6 and 18 months after screening.