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Early Detection & Recurrence of Autism in High-Risk Families

Learn about the infant sibling study on autism, identifying earliest signs, and decreasing age of intervention referral. Discover MRI studies, developmental outcomes, and recurrence rates. Findings include signs by 12 months and implications for clinical practice and future research.

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Early Detection & Recurrence of Autism in High-Risk Families

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  1. Ozonoff Lab • Infant Sibling study • Recurrence risk of autism • Other developmental problems in high risk families • Earliest signs of autism – what, when • Decrease age of identification and referral to intervention • MRI study of high risk infants

  2. UC Davis – UCLA Infant Sibling Study • Phase I, 2003 – 2008 • 223 siblings of children with autism • 124 siblings of children with typical development • Phase II, 2008 – 2013 • 225 siblings of children with autism • 75 siblings of children with typical development 6 mo 12 mo 18 mo 24 mo 36 mo 7 yrs

  3. Developmental Outcomes at 36 Months (UCD and UCLA)

  4. Recurrence Rates(Baby Siblings Research Consortium) • BSRC sample • 12 sites • 664 high risk siblings, 338 low risk siblings • Prevalence of ASD significantly elevated in high risk families • 18.7% of high-risk siblings developed ASD • Even higher recurrence rates in • Male infants (26%) • Multiplex families (32%) • Sex of proband not predictive Ozonoff et al. (2011). Recurrence risk for ASD: A Baby Siblings Research Consortium study. Pediatrics, 128(3), e1-e8.

  5. ASD Outcomes by Risk Group and Infant Gender Ozonoff et al. (2011). Recurrence risk for ASD: A Baby Siblings Research Consortium study. Pediatrics, 128(3), e1-e8.

  6. ASD Outcomes by Multiplex Status and Infant Gender Ozonoff et al. (2011). Recurrence risk for ASD: A Baby Siblings Research Consortium study. Pediatrics, 128(3), e1-e8.

  7. Other Major Findings • Signs evident by 12 months in about half of affected children • Most infants have a period of typical development, followed by a loss of social engagement

  8. Clinical Implications,Future Directions

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