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Opportunities for Collaborative Clinical and Translational Science: The Cincinnati CTSA Experience

Center for Clinical and Translational Science and Training (CCTST). Cincinnati CCTST. Founded in 2005 by the Dean of the College of Medicine and Senior VP for Health Affairs with a $600,000 annual budgetOriginal functionsSpearhead efforts to write institutional grants, e.g., Institutional CTSAAss

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Opportunities for Collaborative Clinical and Translational Science: The Cincinnati CTSA Experience

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    1. Opportunities for Collaborative Clinical and Translational Science: The Cincinnati CTSA Experience Joel Tsevat, MD, MPH Peter Walzer, MD, MSc 28 September 2010 Bethesda, MD

    2. Center for Clinical and Translational Science and Training (CCTST)

    3. Cincinnati CCTST Founded in 2005 by the Dean of the College of Medicine and Senior VP for Health Affairs with a $600,000 annual budget Original functions Spearhead efforts to write institutional grants, e.g., Institutional CTSA Assist faculty in preparing large multidisciplinary, multi-school, and multi-institutional grants Help individual divisions and departments to write T32s Support junior faculty in preparing individual K awards Coordinate the various Master’s programs Award Dean’s Scholars in Clinical Research grants (@ $50k/yr) Establish a Clinical Trials Office

    4. Cincinnati CCTST Institutional CTSA funded in April 2009 ($23M total costs) Partnership among University of Cincinnati Cincinnati Children’s Hospital Medical Center Cincinnati VA Medical Center UC Health University Hospital Greater Cincinnati Community

    5. Governing Board VP for Research, UC (Chair) Dean, College of Medicine Director, Cincinnati VAMC Chair, Department of Pediatrics/Director, Cincinnati Children’s Research Foundation CEO, UC Health University Hospital CEO, UC Physicians

    6. Institutional Support From College of Medicine to VA: >$150k/yr in FTE to the VA Clinical Research Unit (GCRC) adult satellite From VA: $110k/yr for Biomedical Informatics database analyst FTE for CCTST Co-Director, Regulatory Knowledge and Support

    7. Our Program Areas Pilot and Collaborative Translational and Clinical Studies intramural funding program (PCS core) Clinical and Translational Research Informatics Center (CTRIC) Biostatistics, Methods and Ethics in Translational and Clinical Studies (BioMETrCS ) Research Support and Operations (RS&O) Clinical Translational Research Center (CTRC, formerly the GCRC) Community Engagement and Research Research Education, Training and Career Development Enabling Technologies and Stem Cell/Gene Therapy Initiatives for Clinical and Translational Research

    8. Pilot and Collaborative Translational and Clinical Studies Programs Translational Research Initiative (T1) grants: $1.2M/yr Just-In-Time Core Funds grants Retreats/Workshops/Symposia Matching Funds grants Pilot grants for several CCTST program areas (e.g., Community Engagement, BioMETrCS, Ethics) Funding priorities New clinical/translational investigators Basic scientist/clinician collaborations Interdisciplinary studies, esp. multi-institutional (UC East and West Campuses, CCHMC, VAMC, University Hospital)

    9. Clinical and Translational Research Informatics Center Support for investigators Data management using REDCap Survey research using REDCap Survey Clinical trial recruitment using ResearchMatch, Clinical Trial Alert, etc. Assistance with complex research data warehouse queries Researchers’ ToolSet (e.g., http://researchinformatics.org) Education initiatives Clinical and Translational Research Informatics Track in MS in Clinical and Translational Research program ARRA supplement to create online courses

    10. Biostatistics, Methods and Ethics in Translational and Clinical Studies One-stop shopping through Research Central Research designs, specific aims Protocol development Data collection methods Statistical analysis, sample size estimates Manuscript reviews R01, IIR internal reviews Technical writing Mentorship pairing 10 free hours/investigator/year Can earn more through volunteering

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