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Huntington’s Disease

Huntington’s Disease. Rylee Bennett Biology Simonof. What is Huntington’s Disease anyway?. Huntington’s disease is a genetic defect on chromosome four . The defect causes part of the DNA to occur more times than it should .

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Huntington’s Disease

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  1. Huntington’s Disease Rylee Bennett Biology Simonof

  2. What is Huntington’s Disease anyway? • Huntington’s disease is a genetic defect on chromosome four. • The defect causes part of the DNA to occur more times than it should. • In order to fully grasp the concept of HD scientists must learn about the symptoms caused by the HTT gene, the treatment one may need if they have a malfunction of the HTT gene, and the people who have had HD.

  3. How common is Huntington’s? • 30,000 people in the United States alone have Huntington’s. • 1 in 10,000 people suffer from it. • 1 to 3% can get HD without having a family history of it

  4. What is important about the HTT Gene? • The gene provides instruction for making a protein called Huntingtinand contains DNA known as CAG Trinucleotide. • The longer protein breaks up and causes toxins that bind together to make the neurons that disrupt the normal functions.

  5. What are the symptoms of HD? • Symptoms will vary from behavior changes to unusual movement to worsening dementia. • Behavioral Changes: • hallucinations, moodiness, paranoia, psychosis, and restlessness • Unusual Movements: • Facial (grimaces), head turning, sudden jerking of body parts, and slow uncontrollable movements. • Worsening Dementia: • Confusion, personality changes, memory loss, bad judgment, and speech changes.

  6. Is there medicine or a cure? • Currently there is no cure for HD. • When medicine is prescribed it is used to help control the symptoms not the disease itself. • Some medicine that could be prescribed to somebody with HD could be • Amantadine • Tetrabenazine

  7. Lisa Annette Eletto • Wife, mother, and teacher • Born in Los Angeles, California on September 20, 1951 • Her mother also had HD • Did not have any children for the first ten years of their marriage for fear Lisa would pass the gene on to their child. • Finally decided to have a child and later the year she gave birth to her child she was diagnosed with HD

  8. Lisa Annette Eletto • Started losing her balance, having hallucinations, and experienced difficulty performing daily tasks • Stayed in a nursing home for seven years until she passed away • He son was on the way to see her when she died. • She died at age 61, the same as her mother. • Her son, Ryan became more involved with research about Huntington’s Disease after his mother’s death.

  9. What is HD related to? • According to research at Stanford, Parkinson’s disease. • Parkinson’s disease: a progressive movement disorder • Parkinson’s has to do with the nerves which affects movement. • Huntington’s disease has to do with the brain that affects the nerves later on through the disease.

  10. What is HDSA? • HDSA: Huntington’s Disease Society of America • HDSA does researchand works with people who have HD and those who live with them. • HDSA has a website dedicated to educating people about what HD is. (HDSA.org) • HDSA’s website also tells the stories of those who had HD. (Lisa Annette Eltto)

  11. What do you remember? • Huntington’s disease is a disease that is caused by a defect in chromosome…? • A) four B) twenty-two C) HTT D) Huntington • It is caused by a damaged ___ gene. • A) ATP B)HTT C)HD D)DNA • To cure Huntington's disease you need to: • A) Chemo B) Take Tetrabenazine C) No cure • An organization that does research is: • A) HDDA B)HDSA C) ASHD D) CDC • Answers: (1-A) (2-B) (3-C) (4-B)

  12. Works Sited • Works Cited • eMedTV. nervous-system.emedtv. 2006-2014. Webpage. 25 February 2014. • Foundation, Parkinson's Disease. Parkinson's Disease Foundation. 2014. Webpage. 23 Februrary 2014. • Genetics Home Reference. 18 February 2014. Webpage. 25 February 2014. • Huntington's Disease Society of America. 2013. Webpage. 25 February 2014. • Medicine, U.S. National Library of. PubMed Health. 2013. Webpage. 21 February 2014. • Zallen, Doris Teichler. Does it Run in The Family? New Brunswick, New Jersey, and London: Rutgers University Press, 1997. Print. • http://en.hdyo.org/eve/articles/61 • http://drugdiscoveryopinion.com/2008/08/huntington%E2%80%99s-drug-approved-in-us/ • http://www.stanford.edu/group/hopes/cgi-bin/wordpress/2010/06/the-hopes-huntingtons-disease-timeline-text/

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