Most Leading Biotech Companies

www.ciolookindia.com I N D I A MOST LEADING COMPANIES Tech-Upgrades Implementing AI in the Enhancement of Biotechnology Industry Insider Emerging Trends in the Healthcare Sector VOL 07 | ISSUE 08 | 2023

Pioneers in life science technologies MOST LEADING COMPANIES #CIOLOOKINDIA

Editor's Note Leading the Way in Biotech Innovation T he pharmaceutical and biotech industries have seen a significant increase in innovation and technological advancements in recent years. Precision medicine is an innovative approach to patient care that involves tailoring treatments to individual patients based on their genetic makeup, environment and lifestyle. This approach allows for more targeted and personalized treatments, which can lead to better outcomes and reduced side effects. Blockchain technology is being explored as a way to improve the efficiency and security of drug supply chains, clinical trials and medical records. Overall, these innovations are driving significant advances in the pharmaceutical and biotech industries, with the potential to improve patient outcomes, increase efficiency and reduce costs. Some of the innovative companies in the niche are utilizing these trends and benchmarking excellence with core innovation. Spotlighting these gemstones of the pharma and biotech niche, CIOLook India showcases “Most Leading Biotech Companies.” AI and ML are being used to revolutionize drug discovery and development by analyzing large datasets and identifying potential drug candidates faster and more efficiently than traditional methods. Moreover, Gene therapy is an emerging field that involves using genetically engineered viruses to deliver therapeutic genes to patients. This approach has the potential to cure genetic diseases by replacing or repairing faulty genes. Digital health solutions, such as mobile apps and wearables, are being developed to help patients manage their health conditions and provide healthcare providers with real-time data to make informed decisions. Flip through the pages and indulge in the odyssey of prolonged brilliance. Have a delightful read! 3D printing technology is being used to create personalized medical devices and implants, such as prosthetics and dental implants, which can improve patient outcomes and reduce costs. Abhishek Joshi Abhishek Joshi Deputy Editor

CO NT EN TS 08 18 22 Akshar biotech Pvt. Ltd. Reshaping the world of green Energy Profiles diverse genomics Implementing the Next Generation Sequencing rise N’ Shine biotech pvt. ltd. Leveraging scientific temperament and environmental consciousness with the promise of delivering qualitatively superior Tissue Culture planting material and other planting products 14 26 Articles Industry Insider Emerging Trends in the Healthcare Sector Tech-Upgrades Implementing AI in the Enhancement of Biotechnology

Credit Page Descrip?on Sheet I N D I A Editor-in-Chief - Pooja M. Bansal Deputy Editor - Abhishek Joshi MOST LEADING Art & Design Head- Sandeep Tikode Co-designer - Deepanjali Jena COMPANIES A.Vice President - Swapnali Vasaikar Sr. Manager - Tejaswini Whaval Team Lead - Suraj Gadekar BDE - Geetha Reddy JULY 2023 Akshar Biotech Pvt. Ltd. Mr. Bharat G Savaliya, Founder BioResource Biotech Pvt. Ltd. Jagannath Sonawane, Chairman Diverse Genomics Pvt. Ltd. Saurav Jaiswal, CEO and Co-founder Akshar Biotech is an organiza?on established with the principal aim of tapping and developing the renewable energy sources market and making the world a be?er place to live in with less pollu?on. BioResource is a Marke?ng and Distribu?on Company in the field of Life Sciences, Healthcare, Diagnos?cs, Molecular Diagnos?cs, Pharmaceu?cals, BioPharma, Agriculture, Veterinary Science, Food industries, and chemical science. Diverse Genomics, headquartered in Kolkata, India, is a first of its kind cu?ng-edge technology- based premier molecular diagnos?cs company and research organiza?on providing services in Kolkata and Eastern India. Technical Head - Prachi Mokashi Technical Consultant - Prashanth Hiremath Circulation Manager - Tanaji Fartade Research Analyst - Nikita Khadalkar SEO Executive - Ravindra Kadam Kan Biosys Pvt. Ltd. Sandeepa Kanitkar, CMD and Founder Rise n' Shine Biotech Pvt. Ltd. Dr Bhagyashree Pa?l, Chairperson and Managing Director www.ciolookindia.com Kan biosys is a specialized agri-biotech company working in the field of plant nutri?on and pest management, with a vision to be pan India and then global, to bring full plant poten?al to life by microbial inputs and precision agriculture. Rise n’ Shine Biotech is a pioneer in Plant Biotechnology, with ac?vi?es that cover a wide range of interlinked ver?cals like Biotechnology, Floriculture, Hor?culture and Exo?c plant nursery. WE ARE ALSO AVAILABLE ON FOLLOW US ON CONTACT US ON www.twitter.com/ciolookindia www.facebook.com/ciolookindia/ Email -sales@ciolookindia.com For Subscription-www.ciolookindia.com Copyright © 2023 CIOLOOK India, All rights reserved. The content and images used in this magazine should not be reproduced or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission from CIOLOOK India. Reprint rights remain solely with CIOLOOK India.

PROFILE Biotech Companies | July 2023 Seeing the Big Picture, Nailing the Details significant role in long-term planning with an initiative geared towards operational excellence. With his proven leadership and team-building skills, he is suited for the implementation of business strategies as per the vision of the management team. Mr. Bharat G Savaliya is the founder of Akshar Biotech and serves as the President of the same. He brings his industry expertise arising from years of experience in the international design, construction and bioenergy sector. Bharat has always had a knack for seeing what others don’t yet see. With his belief in the word that ‘we have to preserve the Good Earth for our future generations,’ he always looked for ways to protect the earth. This brilliant Theologist has always had the quest to follow the word and work towards the betterment of mankind. This has developed in him an excellent ability to communicate and coordinate with consultants, contractors and clients alike, making him the right choice for project implementation. Reshaping the World of Green Energy “ Mr. Bharat has been just the right person to guide by providing operational and programmatic support the organization. “ In 2011, when very few were fretting about climate change due to greenhouse gas emissions, he had the foresight to start a study of biogas projects through all his globetrotting. The project was with a $5,000 investment that eventually grew into India-based Akshar Biotech, one of Asia’s most promising Bioenergy companies. Bioenergy: The Saviour Talking about Bioenergy as the only solution to environmental problems, Bharat Savaliya emphasizes the importance of bioenergy in farming. He urges both retail and institutional investors to load up on bioenergy farming businesses. “Bioenergy can be the only solution to the depleting energy sources,” says Bharat Savaliya. He has never been afraid to try on different hats and with this, he has vast experience in various fields like Engineering, Project Management and Health Sector Administration. “It is time to give back time and effort to the world and nature itself,” adds Bharat Savaliya. Bharat Savaliya holds a degree in higher secondary and has over nine years of Bioengineering experience in the construction of various industrial and commercial projects. He has held various executive business positions in various national companies around the world. He also won awards for his best engineering practices from the International Consultants group. He serves as a member of the boards of various environmental and social organizations. Moreover, Sadhanaben Savaliya is one of the partners of the company and serves as the Managing Director of the same. Mr. Bharat G Savaliya Founder ‘Do not Waste the Food Waste’ Green energy is the future of a country like India where various sources are available to produce biogas energy. Cow-based biogas manufacturing has become old as newer techniques have emerged. Also, this method could not give the expected results and according to Mr. Bharat, one should try different tactics to solve the problem, just like biogas production through a wide range of food waste. This food waste may include agricultural residue, by-products of horticulture, fruit & vegetables, energy crops such as maize, organic municipal waste of vegetables, waste of gardens and parks, sewage sludge, and more. The energy generated using food waste can be given to grids of electricity and thereby to the nearest areas as well as residential properties. T energy will extinct one day. The reason why must we strive for newer ways of energy generation gives solutions to the problem. Gas, whether it is used for kitchen and household purposes or it is used at bigger industrial levels, is also facing a shortage. To tackle this situation, the Indian Government has taken numerous initiatives with various private industries for the production of cattle-dung biogas over the years. Proving the Value of Good Service Mr. Bharat has been just the right person to guide by providing operational and programmatic support to the organization. He has earned the tag of “A very bright star in the finance department” through an era of wrenching change. He has over 20 years of experience in the finance and accounting industry. He worked on various assignments including project financing activities, budgeting, cash flow forecasting, and setting up and implementing procedures and systems to maintain best accounting and finance practices. He has also worked within the textile and automotive industries too. Being the President of Finance at Akshar Biotech, he is responsible for the accounting and project financing activities. he energy crisis is not new to our generation. From electricity to fuelling vehicles with either petrol, diesel or gas, non-renewable sources of Novel Biogas Plants In Mr. Bharat’s opinion, the future of green energy is in the hands of companies producing energy with a novel and unique approach, to food waste energy production. Akshar Biotech is highly efficient in creating customized Biogas Plants. They include Waste to Energy Biogas Plants, Renewable Energy Biogas Plants, Organic Waste Energy Biogas Plants, and Waste Food Biogas Plants. Different in this race, Akshar Biotech Pvt. Ltd. is taking a unique approach to biogas generation with the help of food waste. Under the guidance of Mr. Bharat G Savaliya, the company has been on the journey of protecting Mother Earth with his brilliant ideas of producing biogas and implementing energy plants. Creating a Storehouse of Value Mr. Yash Savaliya serves as Executive Manager at the company. A man willing to do whatever it takes to succeed in the right way, Yash is clearly motivated by a need for achievement. As Executive Manager, he plays a www.ciolookindia.com www.ciolookindia.com 08 09

Moreover, based on the availability of substrates specific to the location and as per the individual client requirement, the company makes available customized solutions to its clients. All the equipment used in the making of the Biogas Plant is precision engineered to meet the specific requirements of the customers. Additionally, the team provides outstanding technical and maintenance support to the customers. development plant purification plant. That is, the plant uses 50,000 kg of vegetables and food waste to produce biogas. Moreover, it has a capacity of 2200 kg CBG which can be directly supplied to the Gujarat Gas Pipeline network daily. Agriculture Produce Market Committee: The company has a plant in Jamalpur, near Callico mill and in Shree Chimanbhai Jivabhai Patel market yard, Vasana Ahmedabad. These plants produce 3000 cubic meters of row biogas plant from 30,000 kg of vegetable and food waste and cow dung. This gas purification 1200 kg CBG gas plant is used for industrial purposes. Victory Green Energys Pvt. Ltd.: Situated in Vill, Dhamdod, mangrol Near Kosamba, Surat, this plant has 7500 cubic meters of row biogas product. It uses 75,000 kg of cow dung, Napier Grass, vegetable waste, food waste, and sugar factory press mud to produce biogas. It also has a 3200 kg CBG purification plant development and this is directly sent to Bharat Petroleum corporation ltd. Kakadiya Green Energy Pvt. Ltd.: (OP-COMING PROJECT) Situated in Vill, Ranparda (khara) Palitana Bhavnagar, this plant has 6000 cubic meters of row biogas product. It uses 60,000 kg of cow dung, Napier Grass vegetable waste, food waste, and sugar factory press mud to produce biogas. It also has a 3000 kg CBG purification plant development and this is directly sent to Indian oil corporations. Solid and Liquid Fertilizers: Farmers use this for benefits and chemical free farming. • Expanding the Energy Akshar Biotech has not only established its business of producing green energy in parts of Surat but also expanded it to the corners of Gujrat. The company has the following projects: • • Atmiya Vidya Mandir: Situated in Kolibharthana, Kamrej Surat, this plant has the capacity of producing energy from 500 kg of food and vegetable waste. This biogas is sent directly to the kitchen for use. Banshi Gir Gaushala: Situated in Shantipura, SP Ring Road, Ahmedabad, this plant has the capacity of producing biogas from 2000 kg cow dung and this Biogas is also directly sent to the kitchen and boiler. Tejal Gaushala: Situated in Dungri, Mahuva Bardoli, Surat, this plant can produce biogas from 5000 kg cow dung and this Biogas can be used to direct boiler and kitchen. Agriculture Produce Market Committee: In the market of Dumbhal Pune-Kumbharia Road, Surat, this plant has a 5000 cubic meter row biogas • • • • • www.ciolookindia.com www.ciolookindia.com 10 11

Almost everybody is enthusiastic about the promise of biotechnology to cure disease and to relieve suffering. MOST LEADING COMPANIES I N D I A www.ciolookindia.com

Article Emerging Trends in the Healcare Industry Insider T he healthcare sector is undergoing a transformational journey driven by the convergence of biotechnology and technological innovations. This synergy has given rise to groundbreaking solutions that are redefining diagnostics, treatments, and patient care. In this article, we delve into the emerging trends within the healthcare sector that are closely tied to biotechnology, showcasing how these advancements are revolutionizing healthcare delivery and improving outcomes for patients worldwide. Sector The Fusion of Biotechnology and Healthcare Biotechnology, the application of biological knowledge and techniques to develop products and processes, has found a natural ally in the healthcare sector. The integration of biotechnology with healthcare technologies, such as data analytics, artificial intelligence, and precision medicine, has led to a new era of personalized and more effective treatments. Emerging Trends in the Healthcare Sector Precision Medicine and Personalized Treatments: One of the most significant trends is the move towards precision medicine. By analyzing an individual's genetic makeup, lifestyle, and environmental factors, healthcare practitioners can tailor treatments to the specific needs of each patient. This approach maximizes treatment efficacy while minimizing adverse effects. For instance, genetic testing can identify mutations that make certain cancer treatments more effective, ensuring that patients receive treatments most suited to their unique genetic profiles. Also, Foundation Medicine utilizes genomic profiling to identify specific genetic mutations in cancer patients, enabling oncologists to prescribe targeted therapies that have a higher chance of success. www.ciolookindia.com www.ciolookindia.com 14 15

Article Stay in the known Gene and Cell Therapies: Advances in biotechnology have paved the way for gene and cell therapies, offering potential cures for previously untreatable genetic disorders. Gene editing techniques like CRISPR-Cas9 allow scientists to modify defective genes, potentially eliminating the root causes of diseases. Cell therapies, such as CAR-T cell therapy, harness the power of the patient's own immune cells to target and destroy cancer cells. These therapies hold immense promise for transforming the landscape of rare diseases and oncology. molecular structures. This streamlines the drug development process, reducing costs and time-to-market for new treatments. Subscribe to CIOLOOKINDIA Benefits and Transformative Impact Patient-centric Approach: Emerging trends in biotechnology-enhanced healthcare prioritize patients' unique needs, leading to more accurate diagnoses and effective treatments. Disease Prevention and Early Detection: Advanced diagnostics and personalized monitoring enable the identification of diseases at earlier stages, increasing the potential for successful intervention. One example is the treatment of sickle cell anemia using CRISPR to correct the genetic mutation responsible for the disease. Additionally, Novartis's CAR-T cell therapy reprograms a patient's immune cells to target and destroy cancer cells, resulting in remarkable responses in previously untreatable cases of leukemia. Get CIOLOOKINDIA Magazine in Print and Digital on www.ciolookindia.com Improved Outcomes: Precision medicine and therapies designed for specific genetic profiles enhance treatment outcomes, leading to higher success rates and improved patient quality of life. Bioprinting and Organ Regeneration: Biotechnology is making strides in the field of regenerative medicine. Bioprinting, the process of creating functional living tissues using 3D printing technology, holds potential for generating replacement organs and tissues. This could alleviate the global shortage of organ donors and revolutionize organ transplantation. Cost Efficiency: Biotech-driven innovations streamline drug development and treatment approaches, potentially reducing healthcare costs in the long run. Global Health Impact: Emerging trends have the potential to address global health challenges, offering solutions for diseases that were once considered incurable. Organovo, for instance, is working on bioprinting functional human tissues, potentially addressing the shortage of donor organs for transplantation. This technology has the potential to transform the way we approach organ replacement therapies. The Future of Biotechnology-driven Healthcare The future of the healthcare sector, enriched by the integration of biotechnology, holds immense promise. As research advances and technology evolves, personalized treatments, gene therapies, and regenerative medicine will likely become increasingly sophisticated and widely accessible. The healthcare landscape is set to witness a paradigm shift, as biotechnology's role in shaping the industry's trajectory becomes more pronounced. Digital Health and Wearable Devices: The integration of biotechnology and digital health technologies has led to the development of wearable devices that monitor vital signs, track fitness levels, and even diagnose diseases. Continuous monitoring of health parameters allows for early detection of potential health issues, empowering individuals to take proactive steps towards better health. The Apple Watch, for instance, includes features for tracking heart rate, detecting irregular rhythms, and even performing an electrocardiogram. These devices empower individuals to monitor their health in real time and provide valuable data to healthcare professionals. The convergence of biotechnology and healthcare is a transformative journey that is reshaping how diseases are diagnosed, treated, and managed. Emerging trends in this space are pushing the boundaries of what is possible, offering hope for patients and healthcare practitioners alike. By fostering collaboration between researchers, clinicians, policymakers, and industry stakeholders, we can harness the power of biotechnology to propel healthcare into a future where precision, innovation, and improved patient outcomes converge. Subscribe Today Drug Discovery and Development Acceleration: The pharmaceutical industry is benefiting from biotechnology's ability to expedite drug discovery and development. AI- driven algorithms analyze vast datasets to predict drug interactions, identify potential candidates, and optimize I N D I A www.ciolookindia.com 16

PROFILE Biotech Companies | July 2023 DIVERSE Implementing the Next Generation Sequencing The healthcare sector is increasingly turning to biotechnology software to improve patient care and streamline clinical decision-making. Biotech software can be used for tasks such as data analysis, drug discovery and precision medicine. G e n o m i c s A to making genetic screening and testing accessible for all patients. Brief us about the rising need for Biotech software in the healthcare sector. How will it impact how patients receive treatment and the clinical decisions taken by care providers? The healthcare sector is increasingly relying on biotech software to improve patient care and treatment outcomes. The rise of big data, cloud computing, and artificial intelligence has created new opportunities for biotech software to be applied in various aspects of healthcare, including: iming to improve global health by developing deep insights into diseases at the genetic and molecular levels, Diverse Genomics Pvt. Ltd. is committed The organization was incepted and Co-founded by Saurav Jaiswal, with hispassion for gathering knowledge from different arenas of life, especially in science and technology. We caught up with Saurav and discussed how Diverse Genomics aspires to transform medical genomics and personalized therapeutics space. Precision Medicine: Biotech software can be used to analyze large amounts of genomic, proteomic, and clinical data to identify individualized treatment plans for patients. This can help improve the accuracy of diagnoses and predictions of disease progression, leading to better patient outcomes. Below are the highlights of the interview: Kindly tell us the source of inspiration. What led you to venture into the Biotech Industry? My motivation for entering the biotech industry stems from a personal tragedy I experienced. At the young age of 18, I lost my mother to a brain tumor and cancer. This loss inspired me to channel my energy and resources towards improving cancer-related early detection, leveraging cutting-edge biotech genomics sequencing technology. I am driven by a passion to help others avoid the same fate as my mother, and to make a meaningful impact in the fight against cancer. Clinical Decision Making: Biotech software can provide care providers with real-time access to patient data and analytics, helping to support more informed clinical decisions. This can improve the speed and accuracy of diagnoses, reduce medical errors, and lead to better patient outcomes. Saurav Jaiswal, CEO and Co-founder Diverse Genomics Pvt. Ltd. Drug Discovery: Biotech software can help speed up the drug discovery process by enabling researchers to quickly analyze large amounts of data on potential drug targets, accelerating the development of new treatments. Brief us about yourself and shed some light on your role and responsibility at the company. Also, being the CEO, I manage operations across the complete business cycle, starting from HR, R&D, Clinical Oncology, Genomics, Business Development & Sales, and other corporate functions. Subsequently, he helps raise capital and earn revenue for the company's future wealth creation. Telemedicine: Biotech software is playing an increasingly important role in supporting remote patient monitoring and telemedicine, helping to improve access to care for patients in rural or remote areas. In summary, the use of biotech software in healthcare is expected to have a major impact on the way patients receive treatment and the clinical decisions made by care providers. www.ciolookindia.com www.ciolookindia.com 18 19

Biotech Companies | July 2023 Improved Diagnostic Accuracy: WES can be used to identify genetic variations that may be associated with a particular disease, which can help to improve the accuracy of diagnostic testing and reduce the number of false positive and false negative results. What endeavours is the company pursuing to improve its service measures for the clients? POCT "Point of Care Testing," which refers to medical tests that are performed at or near the site of patient care, rather than in a laboratory. Developing new products and services: This can include creating new liquid biopsy tests, expanding the range of cancers that can be detected, and developing new technologies to improve the accuracy and reliability of the tests. By improving the accuracy and speed of diagnoses, reducing medical errors, and supporting personalized treatment plans, biotech software is poised to play a critical role in advancing the quality of patient care in the years to come. What unique biotech solutions does your company offer compared to other companies that have already come up with similar software to resolve current healthcare issues? What factor sets it apart from the rest in the market? We are focused on the non-invasive way of DNA extraction –which is more accessible and hassle-free for patients. We are trying to eliminate cold chain logistics for sample shipment with an advanced IVD-approved sample collection kit, which requires minimum shipment effort. Drug Development: WES can be used to identify genetic variations that may influence an individual's response to a particular drug, which can help to optimize drug development and improve the chances of success in clinical trials. Streamlining Test Processes: Improving the speed, accuracy, and reliability of POCT tests can help provide quicker results and a better experience for clients. Investing in automation and digitalization: This can include implementing automation technologies in the lab and using digital platforms to improve the efficiency and scalability of the company's operations. Providing Patient Education and Support: Providing patients with information and support throughout the testing process can help alleviate any concerns or worries they may have and improve their overall experience. Building a strong team can include: • Recruiting and retaining top talent, • Investing in employee training and development, and • Creating a positive and supportive work environment. Scalability: Leading companies in WES technology have the resources and infrastructure to scale up the production of these tests, making them more accessible to patients. Non-invasive way of collecting samples–Oral swab and Blood. Investing in research and development: This can include funding research projects to develop new products and services and exploring new technologies to improve the company's services and operations. Therefore, companies leading in developing and implementing WES technology play a vital role in advancing our understanding of the genetic basis of diseases and developing new diagnostic and therapeutic options. They are essential in helping to translate genetic discoveries into clinical practice and improve patient outcomes. We have developed our proprietary tests KARK-Early detection for multiple cancer solutions, supported by our unique bioinformatics pipelines, proprietary databases, and collaborators. Liquid Biopsy is a non-invasive method for detecting and analyzing cancer cells using biological fluids such as blood. Advancements in AI and computing have played a significant role in developing liquid biopsy technology. Leveraging new technologies: Biotechnology is advancing rapidly; there are new technologies such as CRISPR, AI, and machine learning that can be integrated into the company's services to improve the diagnosis and treatment of cancer. Our cloud computing power has increased with the help of our partnership with Google for Start-ups (GCP); our bioinformatics and data processing cycle time will be reduced from weeks to days and will increase productivity. Overall, liquid biopsy technology has the potential to revolutionize cancer detection and treatment, allowing for earlier and more accurate diagnosis, as well as providing essential information for treatment decisions. In what way do you consider technological advances a pathway in conducting your operations? In recent years, there has been a significant advancement in the use of AI and computing in DNA sequencing. Some examples include: • Improved algorithms for DNA assembly, which use machine learning techniques to put together the sequences of DNA more accurately and efficiently. • Developing deep learning models for variant calling allows for identifying genetic mutations with greater accuracy. • Use cloud computing and high-performance computing to process large amounts of DNA sequencing data, allowing faster and more efficient analysis. • The development of AI-based tools for interpreting genomic data can help identify genetic markers for diseases and aid in discovering new therapies. • Advancements in CRISPR technology allow precise DNA sequence modifications with the help of AI-based software. What specific R&D operations are your company leading at present? Why do you find them essential in developing BioTech solutions? Whole exome sequencing (WES) is a powerful genetic technique that allows researchers to analyze all the protein- coding regions of the genome (the exome) to identify genetic variants that may be associated with a particular disease or trait. Companies that are leading in the development and implementation of WES technology for research and diagnostic applications are essential in developing biotech solutions for several reasons: Focusing on cost reduction: The company can focus on reducing costs through automation, process optimization, and implementing technology to improve efficiency, which can help to lower the cost of liquid biopsy and make it more accessible to more patients. What advice would you like to give to budding entrepreneurs and enthusiasts who desire to venture into the Biotech Industry? Biotechnology requires significant capital, long gestation periods, and enormous patience. Biopreneurship can be challenging, as it often involves significant financial and technical risks. However, it can also be gratifying, as successful ecopreneurs can substantially impact society and improve human health. Building strategic partnerships: Building partnerships with other biotech companies, pharmaceutical companies, and academic institutions can help the company to access new technologies, funding, and expertise, which can support the company's growth and expansion. How do you envision scaling the company's services and operations in 2023 and beyond? Scaling the company's services and operations in 2023 and beyond will likely involve several different strategies, depending on the specific goals and circumstances of the company. However, some possible ways to scale the company's services and operations include the following: Identifying Genetic Variants: WES allows for identifying genetic variations that may be associated with a particular disease or trait, which is a critical step in understanding the underlying biology of an illness and developing new diagnostic and therapeutic options. Advancement of Personalized Medicine: WES can identify genetic variations that may influence an individual's response to a particular treatment, which can help optimize treatment decisions and improve patient outcomes. Overall, the combination of AI, computing, and DNA sequencing is revolutionizing the field of genomics and has an enormous potential to improve the diagnosis and treatment of diseases, in addition to making gene editing more precise and efficient. Expanding the company's customer base: This can be achieved by increasing marketing and sales efforts, developing new partnerships and collaborations, and entering new markets. www.ciolookindia.com www.ciolookindia.com 20 21

profile Biotech Companies | July 2023 R biotechnology, floriculture, horticulture, and exotic plant nurseries. The business is a pioneer in the field of plant biotechnology based in Pune. ise n' Shine Biotech Pvt. Ltd. is a pioneer in plant biotechnology in India. It engages in an assortment of interconnected vertical operations, including Her optimistic outlook on life, diligence, sheer willpower, perseverance, and dedication made all of this possible. She has a strong commitment to her career. She came from a simple farming background and has set an adventure with the intention to serving farmers of our country with good quality planting material. The company is India's largest plant tissue culture company, and it is certified by the Department of Biotechnology, Government of India, to ISO 9001:2015, DBT, and NCS- TCP. It is headquartered in Pune, Maharashtra, India. The first floriculture company in India to breed the best Gerbera varietals! She has always encouraged, supported, and empowered women. Rural women are encouraged to work and contribute to be financially independent as well as financially support their families. They also learn how to successfully balance their personal and professional life. Empowering women means equipping them with the tools they need to have power and control over their own lives in terms of self-strength to efficiently build women. Dr. Bhagyashree Patil says, "A woman has to be strong in respect of her social acceptance, education, economic status, and most importantly, psychological strength." She also believes that women's empowerment ranges from self- strength to building women's efficiency. She has always had a comprehensive approach to the upliftment of the farming community, and hence her success story is known across the globe. Rise n’ Shine has an 8,000-square-foot, state-of-the-art high-tech research and development lab that have been approved by the Department of Scientific and Industrial Research (DSIR). This facility also contains a special molecular biology lab for virus indexing. The facility's is 2,80,000 Sq.ft laboratory & 1,80,000 square meters of highly regulated greenhouse space produces 100% virus-free plants. The Exotic Nursery within the site, which has a location in Kunjirwadi, Pune comprises 30 acres of poly houses and contains exotic and perennial plants. Customers can also visit the Rise n’ Botanical Boutique at Koregaon Park, Pune, which provides a well- designed exotic store with a unique, unusual, and exquisite collection of plants. Making a Difference Theur is the hub of “Rise n’ Shine Biotech Pvt. Ltd.,” which is home of one of the “Ashtavinayak Lord “Chintamani Ganesha” – the local ecosystem was solely dependent on the Cooperative Sugar Factory. After the closure since 2011, the local population has suffered unemployment which has impoverished the local population and adversely affected households. The determination and hard work of Dr.Bhagyashree Patil took a lead to step the growth from 4000 sqft lab in 2004 to 280,000 sqft lab today. The rapid success of “Rise n’ Shine Biotech Pvt. Ltd.” has given employment opportunities to a large number of women from about 10-12 nearby villages. Total 85% of the employees are women in her company. Rise N' Shine Biotech Pvt. Ltd. Leveraging scientific temperament and environmental consciousness with the promise of delivering qualitatively superior Tissue Culture planting material and other planting products Rise n' Shine Biotech is a one-stop for all tissue culture plant manufacturing and distribution. "Here we take the opportunity to thank all our precious clients, national and international business associates, and horticultural directors, and are grateful to all for the constant support and direction. The RNSB team takes pride in providing quality planting material to all of its growers and farmers! Technical training and guidance’s for the supplied planting material through their expert Technical Managers who are expert in their domain is a continual process. About Dr. Bhagyashree Patil Dr. Bhagyashree Patil, the Chairperson and Managing Director of the Rise n' Shine Group of Companies in Pune and the Pro-Chancellor of the Dr. D. Y. Patil Vidyapeeth , Pune, is the inspiring leader and driving force behind the success of Rise n’ Shine. Regular Medical checkup ,Yoga classes during working hours , Books distributions for the students of nearby villages’ school, Groceries distribution for labour and needy are the part of CSR activities on regular basis from her initiative. Rise n’ Shine is pleased to report that it has now experienced amazing growth in terms of infrastructure expansion and production capacity, enabling it to offer unwavering support to all of its clients in an even greater manner than before. Rise n’ Shine Biotech Pvt. Ltd. has developed a solid network of cooperative ties with reputable international businesses. She is a multifaceted woman-successful entrepreneur, educationist philanthropist and a Super Motivational Bharatnatyam dancer learned at a very short span of time. www.ciolookindia.com www.ciolookindia.com 22 23

Biotech Companies | July 2023 Making Global Alliances India and the Netherlands are celebrating 75 years of diplomatic relations. Today, India and the Netherlands enjoy strong political, economic, and commercial relations. Rise n’ Shine Biotech Pvt. Ltd., India, is always pleased to be associated with valuable Dutch business partners in the Netherlands. Ethiopia, etc., is training. The most recent reports concern Ethiopia's excellent harvest, where Prime Minister, Respected Mr. Abiy Ahmed Ali, visited a farmer's plot and observed the excellent harvest. The entire banana plants in Ethiopia were provided by Rise n’ Shine Biotech. SmrutiPuraskar–2022,” from the auspicious hands of the Hon'ble President of India Shri Ram Nath Kovindji, and “Mahatma Gandhi Samman” at the House of Commons, London, 2022. expansion and production capacity, enabling it to offer unwavering support to all of its clients in an even greater manner than before. Currently, Rise n’ Shine has a 2,80,000-square-foot state-of- the-art, high-tech tissue culture laboratory with a production capacity of more than 45 million plants annually. This enables the company to serve its production alliance partners nationally and internationally for the production of crop varieties from different verticals-floriculture, horticulture, and nursery crops like Gerbera, Carnation, Orchid, Chrysanthemum, Gypsophila, Limonium, Spathiphyllum, Bromeliad, Anthurium, Banana, Strawberry, Pomegranate, Pineapple, Citrus Fruits, Thai Guava, and several other nursery plants. Rise n’ Shine has also received the “Outstanding Achievement Award for Farmers Welfare” (2021), “Leading Plant Biotechnology Company for Banana Plants” at the Fresh India show, New Delhi (2021), “Best Entrepreneur Award 2021” by ICAR-NATIONAL RESEARCH CENTRE FOR BANANA, IRUCHIRAPALLI (2021), “International Excellence Awards for Corporate Leadership” at Dubai, (2019), “Outstanding Women Leadership Award for Business Excellence” at Bangkok (2019),” “Indian Agribusiness excellence award for Women Empowerment” (2017), “Krishi Kanya” (2017), “The Government of Maharashtra Entrepreneurial Award” (2018), “Fastest Growing Indian Company Award” Bangkok, Thailand (2015), “Muktai Gaurav Puraskar” (2008), “Top Management Consortium” (2008), “RashtriyaNirman Ratan Award” (2009), etc. The company’s Chairperson & Managing Director, Dr. Bhagyashree Patil, thanked the farmer family & Hon’ble Prime Minister, Respected Mr. Abiy Ahmed Ali, Ethiopia, for visiting the Ethiopian farmers and appreciating the bumper production received from Rise n’ Shine Biotech Pvt. Ltd., Quality Banana Plants! She states, “We are grateful to the farmers from the Ethiopian family for trusting Rise n’ Shine Banana Plants! And assure Quality planting material always along with the Technical Support.” A friend in need is a friend indeed. Presently, many countries are facing rising energy prices, supply chain disruptions, a decreasing labor supply, etc., which includes the Dutch business sector also. Sector experts expect significant consolidation, with a 30 to 40 percent reduction in businesses. Dr. Patil believes that together, companies will overcome all challenges. She states, "We extend our hand to the entire Netherland business association to do their tissue culture production very much in India and at Rise n’ Shine Biotech Pvt. Ltd., www.risenshine.in ” The market analysis method used by Rise n’ Shine is a continuous process. The team solicits regular client feedback to choose the products that would best serve the needs of the market. The marketing team has the technical expertise and creativity to develop original viewpoints and investigate cutting-edge tactics. Additionally, they foresee market developments, provide timely customer counsel, and ensure client satisfaction and happiness. Likewise, complete technical support and assistance are given to Rise n’ Shine’s national farmers who are growing floriculture products. The company is proud to announce that all its floriculture growers/farmers are successfully earning a profit from their investment and serving the nation in their way. The company has developed Bengaluru, Hyderabad, and many other cities, where it has stories from its successful & hardworking farmers & growers. Dr. Bhagyashree Patil also sees challenges as the perfect opportunity to stretch one's limits to embrace new, positive emotions in the face of adversity while guiding those around oneself. Vision for Expansion An expansion is a road map outlining the approach Rise n’ Shine will take to achieve well-established development in every way. The NewYear 2023 offers a fresh perspective for Rise n’ Shine. Empowering Farmers Rise n’ Shine has always believed in offering its community of farmers and producers solid technical training. The strongest point at which it has communicated with its domestic and international farmers and growers, as well as the company's commercial partners abroad in countries like Awards for Exceptional Work Dr. Bhagyashree Patil, many a time known as a lady with a mission has been conferred with many awards. She was conferred with the prestigious award "Laxmibai Rise n’ Shine is pleased to report that it has now experienced amazing growth in terms of infrastructure www.ciolookindia.com www.ciolookindia.com 24 25

Article Implementing AI in the Enhancement of Biotechnology T biological systems and organisms to create or modify products and processes, has experienced remarkable advancements over the years. With the advent of AI, the synergy between these two domains has paved the way for unparalleled breakthroughs, transforming the landscape of healthcare, agriculture, and environmental sustainability. This article explores the role of AI in biotechnology, its applications, benefits, challenges, and the promising future it holds. he integration of artificial intelligence (AI) into the field of biotechnology has ushered in a new era of possibilities. Biotechnology, the application of For instance, Atomwise employs AI to predict the binding affinity of molecules to target proteins, drastically reducing the time and resources required for identifying potential drug candidates. By analyzing vast datasets, AI algorithms can predict molecular interactions and assess drug safety profiles, resulting in more efficient drug development pipelines. Precision Medicine: AI analyzes patient data, including genetic information and medical history, to tailor treatment plans for individuals. This approach increases treatment efficacy, reduces adverse reactions, and improves patient outcomes. The Confluence of AI and Biotechnology The convergence of AI and biotechnology marks a revolutionary juncture in scientific progress. Artificial intelligence is a branch of computer science that deals with the creation of machines capable of intelligent behaviour. Biotechnology, on the other hand, harnesses biological systems for industrial, medical, and scientific applications. The merging of these two disciplines has led to significant strides in the understanding of complex biological processes and the development of innovative solutions. AI's prowess in analyzing complex patient data is exemplified by IBM's Watson for Oncology. By sifting through medical records, research papers, and clinical trials, this AI system provides oncologists with tailored treatment options based on a patient's genetic profile, medical history, and available evidence. This personalized approach enhances treatment efficacy and patient outcomes. Tech-Upgrades *Applications of AI in Biotechnology Drug Discovery and Development: AI accelerates the drug discovery process by analyzing massive datasets to identify potential drug candidates. Machine learning algorithms predict molecular interactions, analyze protein structures, and simulate drug-target interactions, reducing the time and cost required for drug development. www.ciolookindia.com www.ciolookindia.com 26 27

#ciolookindia Article Genome Editing: AI algorithms aid in designing and optimizing genome editing tools such as CRISPR-Cas9, enabling precise modifications to DNA sequences. This has vast implications in disease research and agriculture. The revolutionary CRISPR-Cas9 technology has been further optimized with AI assistance. AI algorithms predict the outcomes of genetic modifications and guide the design of CRISPR sequences for precision editing. This synergy has expedited genetic research and opened avenues for potential therapeutic interventions in genetic disorders. Resource Optimization: AI-driven bioprocessing reduces resource consumption, making biotechnology more sustainable. Innovation Catalyst: AI inspires the creation of novel technologies, revolutionizing the biotechnology landscape. *Challenges and Considerations Data Quality and Quantity: AI relies on extensive, high- quality datasets. In biotechnology, obtaining sufficient and accurate data can be challenging. Bioprocess Optimization: AI optimizes fermentation processes, protein production, and other bioprocessing tasks. This results in higher yields, improved product quality, and reduced resource consumption. Ethical Concerns: The ethical implications of AI- generated biological entities and the potential for unintended consequences require careful consideration. Biomarker Discovery: AI identifies novel biomarkers indicative of diseases, allowing for earlier diagnosis and better monitoring of patient health. Google's DeepMind demonstrated AI's potential in predicting protein folding, a crucial step in understanding disease mechanisms and designing targeted therapies. This breakthrough has far- reaching implications for drug design and biomarker identification. Interdisciplinary Collaboration: Effective implementation of AI in biotechnology necessitates collaboration between biologists, computer scientists, and domain experts. Regulatory Hurdles: The regulatory framework for AI- augmented biotechnological products and processes is still evolving. Synthetic Biology: AI assists in designing and constructing synthetic biological systems for various applications, including biofuel production and environmental remediation. The Road Ahead The future of AI in biotechnology is promising. As AI algorithms become more sophisticated, they will better simulate complex biological processes and predict outcomes. Researchers are working on developing AI systems that can design completely new proteins, revolutionizing drug development and biocatalysis. AI- driven diagnostics and treatment plans will become increasingly personalized, ushering in an era of precision healthcare. Furthermore, AI's potential to enhance crop yields and optimize agriculture will play a pivotal role in addressing global food security challenges. Agricultural Advancements: AI is transforming agriculture through applications like Plantix. This app employs image recognition and AI algorithms to diagnose crop diseases and nutrient deficiencies by analyzing photos of plants taken by farmers. Such technology aids in identifying problems early, leading to improved crop yields and reduced chemical usage. *Benefits of AI in Biotechnology Speed and Efficiency: AI algorithms process vast amounts of data quickly, accelerating research and development processes. The integration of AI and biotechnology represents a groundbreaking convergence that holds immense potential for advancing human health, environmental sustainability, and scientific knowledge. As the capabilities of AI continue to evolve, its contributions to biotechnology will reshape industries, improve patient care, and unlock previously unimaginable solutions to some of humanity's most pressing challenges. To fully realize these benefits, it is crucial for researchers, policymakers, and stakeholders to collaborate in addressing ethical, regulatory, and technical considerations, ensuring a responsible and impactful integration of AI in the enhancement of biotechnology. Personalization: AI enables tailored treatments and interventions based on individual genetic profiles, enhancing healthcare outcomes. Biotechnology Data-driven Insights: AI uncovers hidden patterns in complex biological data, leading to novel discoveries and insights. www.ciolookindia.com 28

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