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ADC Platform

ADCs are next-generation precision medicines that target specific surface antigens and fight diseases by delivering cytotoxic payload drugs into the antigen-bearing cells. ADCs are trending in immunotherapy and are believed to have high potential and wide applications in treating various types of cancer, fungal or bacterial infections, cardiovascular disorders, and immune diseases. Creative Biolabs and our collaborators are equipped with state-of-the-art research and manufacturing facilities and our advanced technical platforms cover crucial stages in ADC development.

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ADC Platform

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  1. ADCPlatform https://www.creative-biolabs.com/adc

  2. ADC Platform • ADCs are next-generation precision medicines that target specific surface antigens and fight diseases by delivering cytotoxic payload drugs into the antigen-bearing cells. ADCs are trending in immunotherapy and are believed to have high potential and wide applications in treating various types of cancer, fungal or bacterial infections, cardiovascular disorders, and immune diseases.

  3. ADC technologies A B C D E Antibody Design Synthetic Chemistry ADC Manufacturing PtLnX™ 3D Cell Culture

  4. Regular site-directed mutagenesis approaches are often used to introduce amino acid residues such as extra Cys for thiol-based conjugations while our unnatural amino acid incorporation system opens up new alternatives for new conjugation chemistry such as click chemistry A Antibody Design

  5. One essential part in ADC development is the synthesis of the drug-linker complex. This process is accomplished using our advanced organic chemistry synthesis platform (DrugLnk). In the meantime, the design and preparation of customized linker and payload drug modifications and derivatizations are also achieved using this technical platform. B Synthetic Chemistry

  6. With temperature-controlled reactors ranging from small pilot sizes to large manufacturing sizes, our facility can satisfy GMP protein or antibody production at various scales. Organic solvent resistant equipment as well as multiple filtration separation apparatuses also add to the success of large scale production of protein conjugates or ADCs. C ADC Manufacturing

  7. Antibody and payload will be assessed for the feasibility in using such platform and both in vitro and in vivo assay systems will be applied to evaluate the efficacy of the resulted ADC. A Antibody Design

  8. Regular site-directed mutagenesis approaches are often used to introduce amino acid residues such as extra Cys for thiol-based conjugations while our unnatural amino acid incorporation system opens up new alternatives for new conjugation chemistry such as click chemistry D PtLnX™

  9. To help painting a more comprehensive picture of the ADC behavior under these circumstances, Creative Biolabs has adopted and perfected 3D cell culture systems that convert 2-deminsional cell layers into 3-deminsional cell clusters to gain a more accurate ADC penetration and distribution profile in the mimicking of solid tumor micro-environment. E 3D Cell Culture

  10. Creative Biolabs is committed to providing high-quality services to promote the development of ADC and other innovative targeted protein therapeutic agents.

  11. Contact us 45-1 Ramsey Road, Shirley, NY 11967, USA Tel: 1-631-619-7922 Fax: 1-631-207-8356 Email: marketing@creative-biolabs.com

  12. Thanks

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