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adc platform

One essential part in ADC development is the synthesis of the drug-linker complex. This process is accomplished using advanced organic chemistry synthesis platform. In the meantime, the design and preparation of customized linker and payload drug modifications and derivatizations are also achieved using this technical ADC platform.<br>https://www.creative-biolabs.com/adc/platform.htm

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adc platform

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  1. ADC Platform https://www.creative-biolabs.com/adc/

  2. ADCs are next-generation precision medicines that target specific surface antigens and fight diseases by delivering cytotoxic payload drugs into the antigen-bearing cells. ADCs are trending in immunotherapy and are believed to have high potential and wide applications in treating various types of cancer, fungal or bacterial infections, cardiovascular disorders, and immune diseases.

  3. Antibody Design: A variety of strategies are prepared in antibody design and engineering to generate new monoclonal antibodies with accommodating conjugation chemistry sites for the creation of ADCs. Regular site-directed mutagenesis approaches are often used to introduce amino acid residues such as extra Cys for thiol-based conjugations.

  4. Synthetic Chemistry: One essential part in ADC development is the synthesis of the drug-linker complex. This process is accomplished using our advanced organic chemistry synthesis platform (DrugLnk). In the meantime, the design and preparation of customized linker and payload drug modifications and derivatizations are also achieved using this technical platform.

  5. ADC Manufacturing: Large scale ADC preparation is achieved utilizing this technical platform. Creative Biolabs are able to manufacture recombinant antibodies, protein conjugates, and ADCs in cGMP certified facilities.

  6. PtLnX™: Special platform generating ADCs using a short non-cleavable linker with a Platinum core. This novel short linker provides the ADC with good blood stability and highly specialized conjugation chemistry to the His residues. Antibody and payload will be assessed for the feasibility in using such platform and both in vitro and in vivo assay systems will be applied to evaluate the efficacy of the resulted ADC.

  7. 3D Cell Culture: Solid tumors present a unique challenge in the evaluation of ADC efficacy due to the complicated penetration issues. To help painting a more comprehensive picture of the ADC behavior under these circumstances, 3D cell culture systems are used tothat convert 2-deminsional cell layers into 3-deminsional cell clusters to gain a more accurate ADC penetration and distribution profile in the mimicking of solid tumor micro-environment. The “bystander” killing effect of an ADC can also be properly evaluated in these cell clusters.

  8. About • After years of pursuit for perfection, Creative Biolabs has established our leadership in targeted immunotherapy and antibody-drug conjugate (ADC) development. Creative Biolabs offers customers with comprehensive one-stop-shop of all aspects in ADC research and evaluation, ranging from antigen selection, antibody production/optimization, payload-linker synthesis, ADC conjugation, to various stages of ADC characterization and pre-clinical evaluation. Furthermore, inventory also contains an extensive list of linkers, payloads, payload-linker sets, and commonly used ADCs for quick deployment and concept validation.

  9. Contact • 45-1 Ramsey Road, Shirley, NY 11967, USA • Email: marketing@creative-biolabs.com • www.creative-biolabs.com/car-t

  10. THANK YOU

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