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CTRF Leadership Meeting

CTRF Leadership Meeting. Cancer Genomics and Development. of Diagnostic Tools and Therapies. February 4, 2002. Institutional Partners. Principle Objective.

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CTRF Leadership Meeting

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  1. CTRF Leadership Meeting Cancer Genomics and Development of Diagnostic Tools and Therapies February 4, 2002 Institutional Partners

  2. Principle Objective Develop Infrastructure and Intellectual Property that Enhances the Competitiveness of the Partners for Clinical and Extramural Funds

  3. Research Objective • Evaluate gene expression (and genetic changes) in human brain, ovarian, breast and hematopoeticcancers • Link gene expression (and genetic changes) to clinicalfindings and clinical laboratory findings (including histopathologicaldiagnoses) in a common database • Evaluate linked data usingbioinformatics

  4. Funding from CTRF

  5. CTRF Funding Update (12/31/01)

  6. Cost Share Form

  7. CTRF Funding - GMU

  8. CTRF Funding • CTRF CG Administrative Assistant (Jo Ann Breaux) will monitor VCU ledger 5 and cost share accounts. • Plan is to create regular feedback to project PIs in future. • Cost share expenditures not paid from cost share linked ledger 4 account must be documented using ‘In Kind/3rd Party Cost Share form’ obtained from Margie Booker’s office.

  9. Annual Report • Due 12/31/01 • Submitted 12/28/01 • Sections • Purpose • Background • Research Plan • Infrastructure Development • Progress Report • Specific Reportables CTRF

  10. CTRF Annual Report - Progress Report Benign(not growing)vs.Benign(not growing) vs.Benign(growing) vs.Cancer(growing)

  11. CTRF Annual Report - Progress Report Figure 6: Analysis: Total genes probed: ~12,500 Expressed: ~4,500 Not expressed: ~8,000 Figure 5: Example GeneChip Result (DNA Chip)

  12. CTRF Annual Report - Progress Report Figure 7: An example of a spotted DNA microarray with two-color detection of hybridization of probe (surface) with target (sample). The two sectors of 16 x 20 elements is shown following hybridization with two differentially labeled cDNA preparations, Cy3 (pseudocolored green) and Cy5 (pseudocolored red). The overlaying of the green and red images produces the image shown. The hue of each spot, ranging from green to red, indicates the relative expression level for the gene specific for each spot. (Image courtesy Packard Biochip Technologies).

  13. CTRF Annual Report - Progress Report Figure 8: H4IIE cells exposed to 10mg/ml JP8 Jet fuel over 2 hours. Figure 9: Over two fold increase in gene expression

  14. General Approach to Achieve Objectives • Establish Focus Groups to address each of the basic tasks. • Each Focus Group to consist of professionals associated with the CTRF Project with special expertise or knowledge in one or more areas required to address basic tasks. • Structure work within Focus Groups to deal with interrelatedness of basic tasks.

  15. Focus Group • Tissue Bank • Clinical and Pathology Laboratory Data • Database Design • Data Analysis • Quality Assurance in Microarray Analysis • (Chip Fabrication - proposed)

  16. Focus Group Leaders

  17. CTRF - Tissue Bank • Tissue Acquisition System (TAS) Protocol Completed • Submitted to MCC Protocol Review & Monitoring Comm • Contents • Tissue Handling • residual sample • obtained after pathology review • IC - Obtain prior to & following surgery • Primary Data Collection • First Tissue Bank Staff member hired.

  18. Database Design Update Sheet

  19. CTRF - Promoting Focus Group Activity Establish standing weekly or biweekly meeting dates and times

  20. Communication Amongst Members and Focus Groups • CG-TISBK: Tissue Bank • CG-CLNDT: Clinical and Pathology Data • CG-DBDSN: Database Design • CG-ANLDT: Analyze Data (Data Analysis) • CG-QAQC: QAQC • CG-LDRPI: Focus Group Leaders and PIs • CG-MEMBS: All Members 7 - LISTSERVS

  21. LISTSERVS • Address messages to: listname@VENUS.VCU.EDU • Unsubscribe to the listserv by submitting a message with the words SIGNOFF listnameto: LISTSERV@VENUS.VCU.EDU • Subscribe to the listserv by asking the PI with whom you work to submit your name and E-mail address to the Program Director (C.Garrett) • USE the listserv(s) to inform members of your activity or to seek advice from the members.

  22. CTRF - Specific Reportables • Intellectual property reporting - licenses, patents, etc • Publications • New applications identified - CTRF Administrative office • will search for new funding opportunities (SPIN) • will collect CVs, other support, facilities, interest documents • goal - 4 - 8 million in d.c. from CTRF CG Project • Any other discoveries • Federal money leveraged • Private research money leveraged • Advancement of technology and economic development in VA

  23. Old Business • New Business

  24. Next Leadership Meeting Monday March 4, 2002 9:30 am

  25. Diffuse Large Cell Lymphoma - Histology

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