B-Cell Receptor Complex

Aug 20, 2014

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S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. BCR. BCR. CD79A a. CD79B b. CD79B b. 2009 ProteinLounge.com. NH 2. mIgM. NH 2. NH 2. NH 2. L chains. Ig a /Ig b.

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B-Cell Receptor Complex

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S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S BCR BCR CD79A a CD79B b CD79B b 2009 ProteinLounge.com NH2 mIgM NH2 NH2 NH2 L chains Iga/Igb Iga/Igb NH2 NH2 NH2 NH2 H chains H chains B-Cell Receptor Complex BCR Complex CD79A a B-Cell Receptor B-Cell Receptor Complex C

Major Histocompatibility Complex MHC and T cell Receptor TCR Structure and Function

Lecture Objectives. Basic Structure of MHC I and MHC IIBasic Function of MHC I and MHC IIBasic Structure of TCR complexBasic Function of TCR complex. Immune System. INNATENONSPECIFIC CELLS INCLUDE: EPITHELIAL BARRIERS, PHAGOCYTES, COMPLEMENT, NK CELLS. ADAPTIVEANTIGEN (Ag) SPECIFICCELLS I

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T-cell Receptor

T-cell Receptor. Feb 9, 2004. T-cell Receptor.

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Ch 9:T cell receptor

Ch 9:T cell receptor. Where we’re going. Structure of the TCR- alpha and beta chains ( αβ ) The γδ Tcells- know a bit about them The CD3 components and signal transduction-cover much, responsible for just a few concepts. Alloreactivity. Review of TCR’s.

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The T Cell Antigen Receptor Complex

The T Cell Antigen Receptor Complex. Generating Evidence for and isolating the TCR. Generation of cytotoxic T lymphocytes (CTLs) Zinkernagel and Doherty – 1974 demonstrated role of another molecule, MHC got Nobel Prize 1996

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T-cell receptor signalling Toll-like receptor signalling

T-cell receptor signalling Toll-like receptor signalling . SIGNAL TRASDUCTION determines CELL RESPONSE. ?. Adaptive Immunity. Innate Immunity. Signal Transduction in Lymphocytes. Cytokine Receptor Signaling Pathways Chemokine Receptor Signaling Pathways

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T cell receptor signaling

Manifestation of Novel Social Challenges of the European Union in the Teaching Material of Medical Biotechnology Master’s P rogrammes at the University of Pécs and at the University of Debrecen Identification number : TÁMOP-4.1.2-08/1/A-2009-0011.

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B-cell

0D cells. 1D cells. Handle 2. Handle 2 s. Handle 1. Handle 1 s. 2D cells. B-cell. B-cell. B-cell. B-cell. 3D cells. Rope points. Rope. Barrel s. Barrel. Melting egg. Skeleton points. Melting egg s. Skeleton. Hook. Andy. Liquid. Liquid Andy. Andy s. Eggshell. Liquid s.

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T-cell receptor Complex: TCR + CD3

T-cell receptor Complex: TCR + CD3. and  result from differential RNA splicing. Immunoreceptor tyrosine-based activation motif. TCR accessory proteins. Ig domains. Coreceptor interactions. 3D rendering of TCR/MHC I/ Ag. TCR and MHC I. TCR and MHC II. Overview. Early Development

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Structure of T Cell Receptor

Alpha chain. Beta chain. Variable region “V”. CHO. CHO. CHO. CHO. Constant region “C”. Hinge “H ”. Disulfide bridge. +. Transmembrane region. +. +. Cytoplasmic tail. Structure of T Cell Receptor. Structure of T Cell Receptor (TCR).

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T Cell Receptor

T Cell Receptor. W. Robert Fleischmann, Ph.D. Department of Urologic Surgery University of Minnesota Medical School rfleisch@umn.edu (612) 626-5034. Objectives. To understand the central role of T cells To understand how T cell receptors are generated

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Chapter 9 T-Cell Receptor

Chapter 9 T-Cell Receptor. Interaction of ab TCR with class I MHC-peptide. Dec 5, 2006. 你需要學習的課題： T 細胞受體是如何發現的 ? 有什麼特性 ? ab TCR 與 gd TCR 在辨認上有什麼不同 ? TCR 的基因及分子。 T 細胞辨識時，除了 TCR 之外還有哪些 coreceptors ?.

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T Cell Receptor

T Cell Receptor. Hugh B. Fackrell Nov 9, 1998. T Cell Receptor. Assigned Reading Content Outline Performance Ojectives Key terms Key Concepts Short Answer Questions. Assigned Reading. Chapter: 11 pp 264-283 Janis Kuby’s Immunology 3rd Ed. Early Studies Structure of T cell Receptors

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The T-Cell Receptor

The T-Cell Receptor. MHC Restriction TCR Structure & Function Genetic Generation of TCR Diversity Thymus T-cell "Education" and Immunological Tolerance. Folder title: Receptor. November 15, 2006. TCRTitle. Comparison of T-Cell Receptors (TCR) and Antibodies: Differences.

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Secondary Receptor Cell (Hair Cells)

Secondary Receptor Cell (Hair Cells). No axon Output in form of secretion of chemical transmitter agent. Hair Cells. Inner Hair Cells. Outer Hair Cells. Inner Hair Cells (IHC).

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B Cell Receptor Complexes

B Cell Receptor Complexes. SIGMA-ALDRICH. B Cell Receptor Complexes

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Chapter 9 T-Cell Receptor

Chapter 9 T-Cell Receptor. Self-MHC Restriction of the TCR. Structure of TCR. Structural Similarity between TCR and mIgM.  Resembling Fab?. Organization and Rearrangement of TCR Genes. Identifying and Cloning the TCR Genes (Hedrick and Davis, 1984)

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T Cell Receptor (TCR)

T Cell Receptor (TCR). Dr. HARIS BUDI WIDODO. Salah satu karakteristik dari sel limfosit T adalah ekspresi T cell Receptor (TCR) yaitu suatu molekul glikoprotein yang mampu melakukan binding dengan antigen dan molekul MHC secara spesifik.

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T-Cell Receptor Signaling

LAT. B7-2. CaCn. B7-1. MHC-II. TRIM. P A G. Ag. GRB2. GADS. CD4/CD8. C D 4 5. SLP76. CD28. ZAP70. Lck. PKC . SIT. CTLA4. SOS. SHP2. SHP2. PI3K. Caln. VHR. MEK1/2. CARD11. Fyb. PLC g. P. I k B. BCL10. MAP3Ks. Fyn. Fyn. PAK. Calm. ITK. JNK. CSK. Akt. p38.

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T Cell Receptor & T Cell Development

T Cell Receptor & T Cell Development. Questions for the next 2 lectures : How do you generate a diverse T cell population with functional TCR rearrangements? How do you generate a T cell population that is self-MHC restricted? How do you ensure that those diverse T cell

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T-cell Receptor

T-cell Receptor. Ahmad Sh. Silmi Msc,FIBMS IUG Medical Technology Dept. T-cell Receptor.

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B-sejt receptor jelátvitel

Az orvosi biotechnológiai mesterképzés megfeleltetése az Európai Unió új társadalmi kihívásainak a Pécsi Tudományegyetemen és a Debreceni Egyetemen Azonosító szám: TÁMOP-4.1.2-08/1/A-2009-0011.

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Major Histocompatibility Complex and T Cell Receptor

Major Histocompatibility Complex and T Cell Receptor. Major Histocompatibility Complex: History. Transplantation: graft rejection Immune responses: antibody formation Highly polymorphic Bind peptide: recognized by T cells Three-dimensional structure determined by X-ray crystallography. α1.

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B-Cell Receptor Complex

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Presentation Transcript

Major Histocompatibility Complex MHC and T cell Receptor TCR Structure and Function

T-cell Receptor

Ch 9:T cell receptor

The T Cell Antigen Receptor Complex

T-cell receptor signalling Toll-like receptor signalling

T cell receptor signaling

B-cell

T-cell receptor Complex: TCR + CD3

Structure of T Cell Receptor

T Cell Receptor

Chapter 9 T-Cell Receptor

T Cell Receptor

The T-Cell Receptor

Secondary Receptor Cell (Hair Cells)

B Cell Receptor Complexes

Chapter 9 T-Cell Receptor

T Cell Receptor (TCR)

T-Cell Receptor Signaling

T Cell Receptor &amp; T Cell Development

T-cell Receptor

B-sejt receptor jelátvitel

Major Histocompatibility Complex and T Cell Receptor

T Cell Receptor & T Cell Development