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dOrai MSVWTTANNSGLETPTKSPITSSVPRAARSSAVITTGNHQQHHFQHVVAAAVAAATSVATGHQOrai1 ---------------------------------------------------------------Orai2 ---------------------------------------------------------------Orai3 ---------------------------------------------------------------dOrai FQQQFPLHAHPHPQHHSNSPTGSGSNSNNSAGFQRTSISNSLLQFP--PPPPPSSQNQAKPRGOrai1 ------MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGOrai2 --------------------------------MSAELNVPIDPSAPACPEPGHKGMDYRDWVROrai3 -----------------------MKGGEGDAGEQAPLNPEGES--------PAGSATYREFVHdOrai MSVWTTANNSGLETPTKSPITSSVPRAARSSAVITTGNHQQHHFQHVVAAAVAAATSVATGHQOrai1 ---------------------------------------------------------------Orai2 ---------------------------------------------------------------Orai3 ---------------------------------------------------------------dOrai FQQQFPLHAHPHPQHHSNSPTGSGSNSNNSAGFQRTSISNSLLQFP--PPPPPSSQNQAKPRGOrai1 ------MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGOrai2 --------------------------------MSAELNVPIDPSAPACPEPGHKGMDYRDWVROrai3 -----------------------MKGGEGDAGEQAPLNPEGES--------PAGSATYREFVH dOrai HHRTASSSMSQSGEDLHSPTYLSWRKLQLSRAKLKASSKTSALLSGFAMVAMVEVQLDHDTNVOrai1 QSY-----SEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYOrai2 RSY-----LELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYOrai3 RGY-----LDLMGASQHSLRALSWRRLYLSRAKLKASSRTSALLSGFAMVAMVEVQLESDHEYdOrai PPGMLIAFAICTTLLVAVHMLALMISTCILPNIETVCNLHSISLVHESPHERLHWYIETAWAFOrai1 PPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFOrai2 PRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFOrai3 PPGLLVAFSACTTVLVAVHLFALMVSTCLLPHIEAVSNIHNLNSVHQSPHQRLHRYVELAWGFdOrai STLLGLILFLLEIAILCWVKFYDLSPP------------------------------------Orai1 STVIGTLLFLAEVVLLCWVKFLPLKKQPGQPRP---------------------TSKPPASGAOrai2 STVLGILLFLAEVVLLCWIKFLPVDARRQPGP-------------------------PPGPGSOrai3 STALGTFLFLAEVVLVGWVKFVPIGAPLDTPTPMVPTSRVPGTLAPVATSLSPASNLPRSSASdOrai ---------------------------AAWSACVVLIPVMIIFMAFAIHFYRSLVSHKYEVTVOrai1 AANVSTSGIT-------------PGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTDRQFOrai2 H----------------------TGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNOrai3 AAPSQAEPACPPRQACGGGGAHGPGWQAAMASTAIMVPVGLVFVAFALHFYRSLVAHKTDRYKdOrai SGIREL---EMLKEQMEQ-DHLEHHNNIRNNGMNYGASGDIVOrai1 QELNELAEFARLQDQLDHR---GDHPLTPGSHYA--------Orai2 REIEEL---HKLKVQLDGHERSLQVL----------------Orai3 QELEEL---NRLQGELQAV----------------------- Suppl Figure 2

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