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GENÓMICA EVOLUTIVA

GENÓMICA EVOLUTIVA. CIENCIA COMPUTACIONAL: Responsable Dr.Christopher Stephens Investigación Multidisciplinaria Orientada Responsables: Dr. Vladislav Kharchenko y Dr. Rafael Pérez Pascual. Responsable: Dr. Marco Antonio José Valenzuela

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GENÓMICA EVOLUTIVA

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  1. GENÓMICA EVOLUTIVA • CIENCIA COMPUTACIONAL: Responsable Dr.Christopher Stephens • Investigación Multidisciplinaria Orientada • Responsables: Dr. Vladislav Kharchenko y Dr. Rafael Pérez Pascual. • Responsable: Dr. Marco Antonio José Valenzuela • Participantes: Juan R, Bobadilla, Técnico Titular A; Tzipe Govezensky Técnico Titular C; José María Pascual Técnico en Computación; José Antonio García, Dr. en Ciencias Biomédicas; Alma Lara-Sagahón, alumna del Doctorado en Ciencias Biomédicas; Luz calderón, Licenciada en Física; Wentian Li PhD; Eberto Morgado, PhD.

  2. Val GUU Ile AUU Ala GCU Thr ACU Asn AAC Asn AAU Ser AGC Ser AGU Asp GAC Asp GAU Gly GGC Gly GGU Val GUC Ile AUC Ala GCC Thr ACC Sence-antisense transformation Silent mutation Conservative mutation

  3. Amino acid RF Cube Symbol Sextuple Set of triplets Threonine First 1 Thr 010000 ACC,ACA,ACU,ACG Isoleucine 1 Ile 011000 AUC, AUA, AUU Alanine 1 Ala 110000 GCC,GCA,GCU.GCG Valine 1 Val 111000 GUC, GUA, GUU, GUG Asparagine 2 Asn 010100 AAC,AAU Serine 2 Ser 011100 AGC, AGU, UCC, UCA, UCU, UCG Aspartic Acid 2 Asp 110100 GAC,GAU Glycine 2 Gly 111100 GGC,GGA,GGU,GGG Proline Second 3 Pro 000000 CCC,CCA, CCU,CCG Leucine 3 Leu 001000 CUC, CUA, CUU, CUG, UUA, UUG Methionine 4 Met 011011 AUG Histidine Third 5 His 000100 CAC,CAU Arginine 5 Arg 001100 CGC,CGA,CGU,CGG,AGA,AGG Tyrosine 5 Tyr 100100 UAC,UAU Cysteine 5 Cys 101100 UGC,UGU Glutamine 6 Gln 000101 CAA, CAG Stop 6 Stop 100101 UAA,UAG,UGA Tryptophan 6 Trp 101111 UGG Lysine RNA-less 7 Lys 010101 AAA, AAG Glutamic acid 7 Glu 110101 GAA,GAG Phenylalanine 8 Phe 101000 UUC, UUU

  4. Eukaryotes use RNase MRP, snoRNPs Prokaryotes snoRNPs replaced by proteins K selection multiple chromosomes and origins of replication r selection single origins of replication, single chromosome, loss of many RNPs Origin of nucleate cells Origin of single circular genome Last common ancestor uses RNase P, snoRNAs, multiple linear chromosomes Gradual increase in protein catalysts Translation arises, first RNPs Breakthrough organism Extended RNA code type I Breakthrough organism Extended RNA code type II RNA World ancestor of pre-rRNA processed by ribozymes First riboorganism

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