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Memory Circuits of the Cortex and Limbic Systems

Memory Circuits of the Cortex and Limbic Systems. BDNF upregulation during declarative memory formation in monkey inferior temporal cortex. Tokuyama et al. The Basics. The inferior temporal cortex stores visual pair association memory.

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Memory Circuits of the Cortex and Limbic Systems

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  1. Memory Circuits of the Cortex and Limbic Systems

  2. BDNF upregulation during declarative memory formation in monkey inferior temporal cortex Tokuyama et al

  3. The Basics • The inferior temporal cortex stores visual pair association memory. • Tested the hypothesis that BDNF would be upregulated in IT cortex during formation of visual pair-association memory. • Found BDNF was upregulated selectively in area 36 of IT cortex during PA learning, but not in areas involved in earlier stages of visual processing. • Suggests that BDNF contributes to reorganization of neural circuits for visual long-term memory formation in the primate

  4. Methods:Three experimental strategies • Intra-animal comparison of mRNA expression • A visual memory task as the control vs. a no-task condition • Trained the monkeys to first learn a “rule” or “strategy” component of the tasks with training stimulus sets; a test stimulus was then introduced for new learning of declarative components.

  5. Increased BDNF and trk-B mRNA expression in cortical and limbic regions following formation of a social recognition memory • Kevin D. Board et al

  6. The Basics • Sheep recognition: olfactory evolving to visual • Investigate BDNF & trk-B mRNA expression 4.5 hours post partum in olfactory/visual systems

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