An Academic Health Sciences Centre at the heart of a world city....

1. An Academic Health Sciences Centre at the heart of a world city....

2. Four high-performing institutions • Guy’s and St Thomas’ (GSTT) • King’s College Hospital (KCH) • South London and Maudsley (SLaM) • King’s College London (KCL) The partners – four highly-performing institutions each bringing complementary and distinctive contributions • Excellence in clinical service • Comprehensive portfolio of excellent quality innovative services • International recognition: in renal and liver disease, dermatology, haematology, children’s, neurosciences, foetal medicine and mental health Enfield Barnet Harrow Haringey Redbridge Waltham Forest Havering Brent Islington Hillingdon Hackney Camden Barking Newham Tower Westminster Hamlets Ealing City Ken. & Southwark Chel . Hammersmith • Excellence in education • Unique breadth of education and training to 9,500 students • At the forefront of innovation and exploiting new technology • Capacity building for translational research • Excellence in research • One of top 5 biomedical research universities in UK (2008 RAE) • Six MRC Centres, three NIHR Research Centres and BHF Centre of Excellence • Institute of Psychiatry and SLaM leading mental health research centre in Europe Hounslow Greenwich Lambeth Bexley Wandsworth Richmond Lewisham Merton Bromley Kingston Croydon Sutton ’ ’ -

3. UK • Founder member of Global Medical Excellence Cluster (GMEC) • Will partner with the UK Centre for Medical Research and Innovation (MRC) • International • Existing collaborations and relationships (e.g. Johns Hopkins, UNC, UCSF, Somaliland, Zambia) • Maudsley International Enfield Barnet Harrow Haringey Redbridge Waltham Forest Havering Islington Brent Hillingdon Hackney Camden Barking Newham Tower Westminster Hamlets Ealing City Ken. & Southwark Chel . Hammersmith Hounslow Greenwich Lambeth Bexley Wandsworth Richmond Lewisham Merton Bromley Kingston • London • Substantial collaboration already (e.g. Allergy and Environment and Health) • Three AHSCs working closely together to make London one of the world’s leading centres of healthcare • South East • Established networks across South East (e.g. Cancer and Neurosciences) • Working to establish Health and Innovation Clusters across Southern England Croydon Sutton Collaboration – working to make London a leading ‘healthcare city’

4. Neuroscience, Neurological Disease and Mental and Behavioural Disorders Cardiovascular Disease, including Imaging Asthma, Allergy, Environment and Health Oral Disease / Dentistry Transplantation, Regenerative Medicine / Stem Cells Dermatology Medical Genetics Diabetes, Obesity and Metabolic Disease; Healthy Living Cancer, including Palliative Care and Cancer Imaging Strategic priorities – existing excellence, emerging strengths Existing comprehensive international profile, excellence in research and clinical service delivery Emerging strengths of relevance to the local population

5. Lambeth Southwark Lewisham Greenwich Croydon Bromley Bexley Key In line with London average Better than London average Worse than London average The population – focus on local health needs and reducing inequalities Health Indicator Binge drinking adults Deaths from smoking Drug Misuse Early deaths: Cancer Early deaths: Heart disease& stroke Healthy eating adults Hospital stays due to alcohol Infant Mortality Life expectancy Mental Illness Obese Adults Obese Children Physically active adults Teenage Pregnancy Tuberculosis Violent Crime Source : Department of Health Community Health Profiles 2008

6. The vision – a radical change in healthcare • To advance health and well-being by integrating world-class research, care, education and training through: • Translating research more rapidly into clinical practice and effectively disseminating these advances through education and training • Harnessing the power of discovery science to transform the nature of healthcare by moving from treatment towards population screening and disease prevention • Recognising the special needs and inequalities in health among the local population and addressing these through earlier intervention and personalised medicine, as well as helping local people to maintain, improve and enhance their health

7. The key building blocks of the AHSC The structure – Clinical Academic Groups Cardiovascular Dementia and Older People’s Mental Health DiabetesandObesity Other Clinical Academic Groups • All clinical services and translational research • Strategy for delivery of the tripartite mission • Devolved budgets CLINICAL ACADEMIC GROUPS

8. Basic Sciences Institute Drive basic discovery NIHR BiomedicalResearch Centres Drive translation Health Service ResearchAnd Evaluation Evaluate Research AndInnovation Services Efficient infrastructureto deliver translation Disseminate knowledge,train the next generation Disorder- / Research-based training and education Disorder / Research EDUCATION ACADEMY Based Training and Education The structure – accelerating translation and disseminating knowledge Cardiovascular Dementia and Older People’s Mental Health DiabetesandObesity Other Clinical Academic Groups CLINICAL ACADEMIC GROUPS

9. SLaM KCH GSTT KCL Partnership Board AHSC Executive Basic Sciences Institute Drive basic discovery NIHR BiomedicalResearch Centres Drive translation Health Service ResearchAnd Evaluation Evaluate Research AndInnovation Services Efficient infrastructureto deliver translation Disseminate knowledge,train the next generation Disorder- / Research-based training and education Disorder / Research EDUCATION ACADEMY Based Training and Education The structure – integrating leadership and linking resources to the vision Cardiovascular Dementia and Older People’s Mental Health DiabetesandObesity Other Clinical Academic Groups CLINICAL ACADEMIC GROUPS

10. Cardiovascular CAG – added value of the AHSC • Non-invasive aortic valve replacement delivered jointly across GSTT and KCH • Primary PCI – first 24/7 programme in UK, pilot site for the DH, 400 patients p.a. • MR-guided cardiac catheterisation N.B. for electrophysiology Clinical innovation Research • Integration of basic science and clinical programme e.g. ischaemia reperfusion, cytoprotection, novel interventions monitored by MR Education and Training • Dissemination of best practice to local networks and beyond • Public education to raise awareness / access • Ethnicity and risk • Non-invasive diagnosis of EC dysfunction • Targeted early intervention Prevention

11. What will be different? Shorter translational pathways • We will: • Work with partners in our local communities to identify ill-health at the earliest possible opportunity • Train all of our nurses to ensure that every patient has the opportunity to grant their consent to participate in research during their first contact • Build on the CRIS IT system to optimise the ability to utilise the clinical patient record to support research • Create a biobank to inform research through taking samples during treatment from all consenting patients • Ultimately: • Providing the best and most up-to-date treatments and the best service delivered consistently by the best trained staff in the most appropriate setting to ensure the best outcomes for all of our patients

12. Now Future What will be different? Benefits for patients Partnership with integrated leadership, shared purpose and investment priorities Four independent organisations with different visions and investment priorities CAGs responsible for developing and delivering the tri-partite mission Lack of integration of clinical, research and education due to organisational barriers Shorter translational pathways delivered through our new research infrastructure Long translational cycle time with low levels of patient participation in research Faster and wider dissemination of knowledge through the Education Academy Slow adoption of innovation and best practice locally, nationally, internationally Increased resources invested in prevention and on delivering care in the community Focus of clinical and academic resources on treating ill-health in a hospital setting Reduced inequalities, better health through most up-to-date treatments to patients General poor health of our local population with wide inequalities in health and access