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OBAT SISTEM SARAF OTONOM

OBAT SISTEM SARAF OTONOM. Disampaikan Oleh : Ida Mukhlisa , S.Farm,Apt. Disampaikan Oleh : Ida Mukhlisa , S.Farm,Apt. Secara anatomi SSO dibagi menjadi 2 bagian besar : Parasimpatis ( Kraniosakral )

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OBAT SISTEM SARAF OTONOM

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  1. OBAT SISTEM SARAF OTONOM DisampaikanOleh : Ida Mukhlisa, S.Farm,Apt

  2. DisampaikanOleh : Ida Mukhlisa, S.Farm,Apt • Secaraanatomi SSO dibagimenjadi 2 bagianbesar : • Parasimpatis (Kraniosakral) • Secaraanatomi, serabutparasimpatisberadadikraniosakralpada spinal cord, mempunyaiserabutpreganglion yang panjangdanserabutpostganglion yang pendek. Ganglion dekatatauadapadajaringan target. • 2. Simpatis (Thorakolumbar) • Secaraanatomi, serabutsimpatisberadadibagianthorakolumbar spinal cord, memilikiserabutpreganglionpendekdengansinapsdalam ganglia yang membentukrantai – batangsimpatik. • Sebagianbesarjarignandiinervasiolehsarafparasimpatikdansimpatik, tetapiadabeberapapengecualian.

  3. Flow Chart SistemSaraf

  4. ReseptorNeurotransmitter SSO

  5. JenisReseptorOtonom

  6. Alpha Receptor

  7. AktivitasSarafOtonomterhadapBeberapaSistem Organ

  8. 1. AgonisAdrenergikKerjaLangsung Selectivitasrelatifagonisadrenoreseptor

  9. AgonisAdrenergik

  10. 3. AgonisAdrenergikKerjaCampuran Ephedrine • Alkaloid yang berasaldaritanaman, menstimulasisecaralangsungreseptor dan  sertamenstimulasipelepasannorepinephrine. • Diabsorbsisecaraoral,diekskresikandalambentuk yang tidakdiubahmelaluiurin. • Meningkatkanteanandarahmelaluistimulasi  dan . Merupakan bronchodilator. • Ephedrine menghasilkanstimulasiringanterhadap SSP  siaga  rasa lelahdanngantuk. Digunakansebagaidekongestanjuga. Toleransidantakhfilaksisdiketahuidenganbaik. Pseudoephedrine • Digunakanpadaalergi rhinitis dan flu biasa. • Padadosistinggimenyebabkan TD  danmenstimulasijantung • Diberikansecara oral. Jikadicampurdapatmenstimulasi SSP.

  11. AntagonisAdrenergik • They are subclassified on the basis of  selectivity, partial agonist activity, local anesthetic action and lipid solubility. Classification : • Non Selective  blockers: e.g. Propranolol, Satalol, PindololTimolol and Nadolol. • Cardioselective  blockers: e.g. Atenolol, Acebutolol, Metoprolol, Esmolol. • Drugs whick block both  and  adrenergic receptors e.g. Labetalol. • Non selective  blockers with vasodilator action as carvedilol. N.B :Acebutolol, atenolol and nadolol are less lipid soluble and probably enter the CNS to a lesser extent.

  12. AntagonisAdrenergik

  13. SelektivitasRelatifAntagonisuntukAdrenoreseptor

  14. ReseptorKolinergik Reseptorkolinergikterbagi 2 type : • ReseptorAChNikotinik • Reseptor Ach Muskarinik Banyakdijumpaisistemsarafdiperifermaupundipusat. Keduanyaberbedadalamhaltransduksisinyalnya.

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